Circulating Platelet Count and Glycans

Overview

Journal Curr Opin Hematol

Specialty Hematology

Date 2021 Oct 4

PMID 34605444

Citations 3

Authors

Leonardo Rivadeneyra

Herve Falet

Karin M Hoffmeister

Affiliations

Soon will be listed here.

Abstract

Purpose Of The Review: This review highlights recent advancements in understanding the regulation of platelet numbers, focusing on mechanisms by which carbohydrates (glycans) link platelet removal with platelet production in the bone marrow in health and disease.

Recent Findings: This review is focused on the role of carbohydrates, specifically sialic acid moieties, as a central mediator of platelet clearance. We discuss recently identified novel mechanisms of carbohydrate-mediated platelet removal and carbohydrate-binding receptors that mediate platelet removal.

Summary: The platelet production rate by megakaryocytes and removal kinetics controls the circulating platelet count. Alterations in either process can lead to thrombocytopenia (low platelet count) or thrombocytosis (high platelet count) are associated with the risk of bleeding or overt thrombus formation and serious complications. Thus, regulation of a steady-state platelet count is vital in preventing adverse events. There are few mechanisms delineated that shed light on carbohydrates' role in the complex and massive platelet removal process. This review focuses on carbohydrate-related mechanisms that contribute to the control of platelet numbers.

Citing Articles

Mechanistic and Therapeutic Implications of Protein and Lipid Sialylation in Human Diseases.

Zhong X, DAntona A, Rouse J Int J Mol Sci. 2024; 25(22).

PMID: 39596031 PMC: 11594235. DOI: 10.3390/ijms252211962.

Pretreatment level of serum sialic acid predicts both qualitative and quantitative bone metastases of prostate cancer.

Sun J, Tian T, Wang N, Jing X, Qiu L, Cui H Front Endocrinol (Lausanne). 2024; 15:1338420.

PMID: 38384968 PMC: 10880016. DOI: 10.3389/fendo.2024.1338420.

Beyond Hemostasis: Platelet Innate Immune Interactions and Thromboinflammation.

Mandel J, Casari M, Stepanyan M, Martyanov A, Deppermann C Int J Mol Sci. 2022; 23(7).

PMID: 35409226 PMC: 8998935. DOI: 10.3390/ijms23073868.

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