Tunicamycin Induces Hepatic Stellate Cell Apoptosis Through Calpain-2/Ca-Dependent Endoplasmic Reticulum Stress Pathway

Overview

Journal Front Cell Dev Biol

Specialty Cell Biology

Date 2021 Oct 4

PMID 34604209

Citations 5

Authors

Haiying Liu

Linyu Dai

Ming Wang

Fumin Feng

Yonghong Xiao

Affiliations

Soon will be listed here.

Abstract

It has been reported that calpain/caspase-mediated apoptosis induced by endoplasmic reticulum stress (ERS) in hepatic stellate cells (HSCs) by previous studies. At present, the activation of HSC is an important cause of liver fibrosis, and the induction of HSC apoptosis plays an irreplaceable role in reversing liver fibrosis. Therefore, it is of great significance to explore mechanisms of action that can induce HSC apoptosis for the reversal of hepatic fibrosis and the clinical prevention and treatment of hepatic-fibrosis-related diseases such as hepatitis, cirrhosis, and liver cancer. In the current study, we demonstrated that tunicamycin (a novel ERS inducer) can induce the apoptosis of HSCs and increase the concentration of intracellular Ca and the expression of ERS protein GRP78, apoptosis protein caspase-12, and Bax, while it can decrease the antiapoptosis protein expression of Bcl-2. Our findings indicate that tunicamycin can induce HSCs apoptosis through calpain-2/Ca-dependent ERS pathway.

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