Advanced Nano-Carriers for Anti-Tumor Drug Loading

Overview

Journal Front Oncol

Specialty Oncology

Date 2021 Oct 4

PMID 34604097

Citations 7

Authors

Jia Xiang

Rui Zhao

Bo Wang

Xinran Sun

Xu Guo

Songwen Tan

Wenjie Liu

Affiliations

Soon will be listed here.

Abstract

Chemotherapy is one of the important means of tumor therapy. However, most of the anti-tumor drugs that currently used in clinic are hydrophobic non-specific drugs, which seriously affect the efficacy of drugs. With the development of nanotechnology, drug efficacy can be improved by selecting appropriate biodegradable nanocarriers for achieving the controlled release, targeting and higher bioavailability of drugs. This paper reviewed the research progress of anti-tumor drug nanoparticle carriers, which mainly summarized the materials used for anti-tumor drug nanoparticle carriers and their effects in anti-tumor drugs, as well as the targeted drug delivery methods of anti-tumor drugs based on nanocarriers.

Citing Articles

A novel process for transcellular hemoglobin transport from macrophages to cancer cells.

Braniewska A, Skorzynski M, Sas Z, Dlugolecka M, Marszalek I, Kurpiel D Cell Commun Signal. 2024; 22(1):570.

PMID: 39605056 PMC: 11603754. DOI: 10.1186/s12964-024-01929-8.

Current status and prospects of MIL-based MOF materials for biomedicine applications.

Lin Z, Liao D, Jiang C, Nezamzadeh-Ejhieh A, Zheng M, Yuan H RSC Med Chem. 2023; 14(10):1914-1933.

PMID: 37859709 PMC: 10583815. DOI: 10.1039/d3md00397c.

Recent Advances in Nanobiotechnology for the Treatment of Non-Hodgkin's Lymphoma.

Liu S, Xu M, Zhong L, Tong X, Qian S Mini Rev Med Chem. 2023; 24(9):895-907.

PMID: 37724679 DOI: 10.2174/1389557523666230915103121.

The Art of War with : Targeting Mex Efflux Pumps Directly to Strategically Enhance Antipseudomonal Drug Efficacy.

Avakh A, Grant G, Cheesman M, Kalkundri T, Hall S Antibiotics (Basel). 2023; 12(8).

PMID: 37627724 PMC: 10451789. DOI: 10.3390/antibiotics12081304.

Smart Polymeric Nanoparticles in Cancer Immunotherapy.

Yu Z, Shen X, Yu H, Tu H, Chittasupho C, Zhao Y Pharmaceutics. 2023; 15(3).

PMID: 36986636 PMC: 10056399. DOI: 10.3390/pharmaceutics15030775.

References

Robbins P, Ghivizzani S . Viral vectors for gene therapy. Pharmacol Ther. 1998; 80(1):35-47. View

Yang H, Hua M, Liu H, Huang C, Tsai R, Lu Y . Self-protecting core-shell magnetic nanoparticles for targeted, traceable, long half-life delivery of BCNU to gliomas. Biomaterials. 2011; 32(27):6523-32. DOI: 10.1016/j.biomaterials.2011.05.047. View

Yin H, Kanasty R, Eltoukhy A, Vegas A, Dorkin J, Anderson D . Non-viral vectors for gene-based therapy. Nat Rev Genet. 2014; 15(8):541-55. DOI: 10.1038/nrg3763. View

Wu G, Li J, Yue J, Zhang S, Yunusi K . Liposome encapsulated luteolin showed enhanced antitumor efficacy to colorectal carcinoma. Mol Med Rep. 2017; 17(2):2456-2464. PMC: 5783491. DOI: 10.3892/mmr.2017.8185. View

Shalaby S, Khater M, Perucho A, Mohamed S, Helwa I, Laknaur A . Magnetic nanoparticles as a new approach to improve the efficacy of gene therapy against differentiated human uterine fibroid cells and tumor-initiating stem cells. Fertil Steril. 2016; 105(6):1638-1648.e8. PMC: 4971775. DOI: 10.1016/j.fertnstert.2016.03.001. View

Tapeinos C, Battaglini M, Ciofani G . Advances in the design of solid lipid nanoparticles and nanostructured lipid carriers for targeting brain diseases. J Control Release. 2017; 264:306-332. PMC: 6701993. DOI: 10.1016/j.jconrel.2017.08.033. View

Pastorino F, Brignole C, Marimpietri D, Sapra P, Moase E, Allen T . Doxorubicin-loaded Fab' fragments of anti-disialoganglioside immunoliposomes selectively inhibit the growth and dissemination of human neuroblastoma in nude mice. Cancer Res. 2003; 63(1):86-92. View

Maeda H, Wu J, Sawa T, Matsumura Y, Hori K . Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a review. J Control Release. 2000; 65(1-2):271-84. DOI: 10.1016/s0168-3659(99)00248-5. View

Nygren P . What is cancer chemotherapy?. Acta Oncol. 2001; 40(2-3):166-74. DOI: 10.1080/02841860151116204. View

10.

Barratt G . Colloidal drug carriers: achievements and perspectives. Cell Mol Life Sci. 2003; 60(1):21-37. PMC: 11138927. DOI: 10.1007/s000180300002. View

11.

Pugazhendhi A, Edison T, Karuppusamy I, Kathirvel B . Inorganic nanoparticles: A potential cancer therapy for human welfare. Int J Pharm. 2018; 539(1-2):104-111. DOI: 10.1016/j.ijpharm.2018.01.034. View

12.

Schulze-Lefert P, Schulz W, Hahlbrock K, Dangl J . Functional architecture of the light-responsive chalcone synthase promoter from parsley. Plant Cell. 1989; 1(7):707-14. PMC: 159807. DOI: 10.1105/tpc.1.7.707. View

13.

Huang H, Barua S, Sharma G, Dey S, Rege K . Inorganic nanoparticles for cancer imaging and therapy. J Control Release. 2011; 155(3):344-57. DOI: 10.1016/j.jconrel.2011.06.004. View

14.

Subhan M, Yalamarty S, Filipczak N, Parveen F, Torchilin V . Recent Advances in Tumor Targeting via EPR Effect for Cancer Treatment. J Pers Med. 2021; 11(6). PMC: 8234032. DOI: 10.3390/jpm11060571. View

15.

Li Y, Liu T, Zhang G, Ge Z, Liu S . Tumor-targeted redox-responsive nonviral gene delivery nanocarriers based on neutral-cationic brush block copolymers. Macromol Rapid Commun. 2013; 35(4):466-73. DOI: 10.1002/marc.201300719. View

16.

Chen M, He Y, Chen X, Wang J . Quantum dots conjugated with Fe3O4-filled carbon nanotubes for cancer-targeted imaging and magnetically guided drug delivery. Langmuir. 2012; 28(47):16469-76. DOI: 10.1021/la303957y. View

17.

Deng Z, Zhen Z, Hu X, Wu S, Xu Z, Chu P . Hollow chitosan-silica nanospheres as pH-sensitive targeted delivery carriers in breast cancer therapy. Biomaterials. 2011; 32(21):4976-86. DOI: 10.1016/j.biomaterials.2011.03.050. View

18.

Zhang Y, Gallis B, Taya M, Wang S, Ho R, Sasaki T . pH-responsive artemisinin derivatives and lipid nanoparticle formulations inhibit growth of breast cancer cells in vitro and induce down-regulation of HER family members. PLoS One. 2013; 8(3):e59086. PMC: 3597601. DOI: 10.1371/journal.pone.0059086. View

19.

Zheng L, Zhang X, Wang Y, Liu F, Peng J, Zhao X . Fabrication of Acidic pH-Cleavable Polymer for Anticancer Drug Delivery Using a Dual Functional Monomer. Biomacromolecules. 2018; 19(9):3874-3882. DOI: 10.1021/acs.biomac.8b01001. View

20.

Winnik F, Maysinger D . Quantum dot cytotoxicity and ways to reduce it. Acc Chem Res. 2012; 46(3):672-80. DOI: 10.1021/ar3000585. View