Genetic Variations of and Genes Are Associated With Increased Susceptibility and Clinical Outcome of Non-Small-Cell Carcinoma Patients

Overview

Journal Front Oncol

Specialty Oncology

Date 2021 Oct 4

PMID 34604057

Citations 2

Authors

Foteinos-Ioannis D Dimitrakopoulos

Anna G Antonacopoulou

Anastasia E Kottorou

Melpomeni Kalofonou

Nikolaos Panagopoulos

Dimitrios Dougenis

Thomas Makatsoris

Vasiliki Tzelepi

Angelos Koutras

Haralabos P Kalofonos

Affiliations

Soon will be listed here.

Abstract

Background: Immune system-related receptors CD40 (tumor necrosis factor receptor superfamily member 5), BAFFR (tumor necrosis factor receptor superfamily member 13C), and LTβR (tumor necrosis factor receptor superfamily member 3) play a pivotal role in non-small-cell lung cancer (NSCLC). To further evaluate their role in NSCLC, rs1883832 (T>C), rs7290134 (A>G), and rs10849448 (A>G) single-nucleotide polymorphisms (SNPs) were investigated regarding their impact in risk and clinical outcome of NSCLC patients.

Methods: The three selected SNPs were evaluated in 229 NSCLC patients and 299 healthy controls, while CD40, BAFFR, and LTβR protein expression was assessed by immunohistochemistry in 96 tumor specimens from NSCLC patients.

Results: In total, rs1883832 was associated with NSCLC risk, with the T allele, after adjusting for cofactors, being related to increased risk (p = 0.007; OR 1.701). Moreover, the CT genotype was associated with increased risk (p = 0.024; OR 1.606) and poorer 5-year overall survival (OS) after adjusting for cofactors (p = 0.001, HR 1.829), while CC was associated with higher CD40 expression in tumorous cells (p = 0.040) and in stromal cells (p = 0.036). In addition, AA homozygotes for the rs10849448 had increased risk for NSCLC in multivariate analysis (p = 0.008; OR, 2.106) and higher LTβR membranous expression (p = 0.035). Although rs7290134 was associated with BAFFR membranous expression (p = 0.039), rs7290134 was not associated with neither the disease risk nor the prognosis of NSCLC patients.

Conclusions: In conclusion, rs1883832 and rs10849448 seem to be associated with increased risk for NSCLC, while rs1883832 is also associated with OS of patients with NSCLC.

Citing Articles

The clinical significance of endoplasmic reticulum stress related genes in non-small cell lung cancer and analysis of single nucleotide polymorphism for CAV1.

Li S, Chen J, Zhou B Front Mol Biosci. 2024; 11:1414164.

PMID: 39165641 PMC: 11334084. DOI: 10.3389/fmolb.2024.1414164.

The rs1883832 Polymorphism (CD40-1C>T) Affects the Intensity of IgA Responses after BNT162b2 Vaccination.

Speletas M, Bakaros E, Peristeri A, Voulgaridi I, Sarrou S, Paliatsa V Int J Mol Sci. 2022; 23(22).

PMID: 36430533 PMC: 9697403. DOI: 10.3390/ijms232214056.

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