Novel Diagnostic Options for Endometriosis - Based on the Glycome and Microbiome

Overview

Journal J Adv Res

Specialties General Medicine
Science

Date 2021 Oct 4

PMID 34603787

Citations 17

Authors

Zsuzsanna Kovacs

Louise Glover

Fiona Reidy

John MacSharry

Radka Saldova

Affiliations

Soon will be listed here.

Abstract

Background: Endometriosis is a chronic gynaecological disease whose aetiology is still unknown. Despite its prevalence among women of reproductive age, the pathology of the disease has not yet been elucidated and only symptomatic treatment is available. Endometriosis has high latency and diagnostic methods are both limited and invasive.

Aim Of Review: The aim of this review is to summarise minimally invasive or non-invasive diagnostic methods for endometriosis and their diagnostic efficiencies. Furthermore, we discuss the identification and diagnostic potential of novel disease biomarkers of microbial or glycan origin.

Key Scientific Concepts Of Review: Great efforts have been made to develop minimally invasive or non-invasive diagnostic methods in endometriosis. The problem with most potential biomarker candidates is that they have high accuracy only in cases of severe disease. Therefore, it is necessary to examine other potential biomarkers more closely. Associations between gastrointestinal and genital tract microbial health and endometriosis have been identified. For instance, irritable bowel syndrome is more common in women with endometriosis, and hormonal imbalance has a negative impact on the microbiome of both the genital tract and the gastrointestinal system. Further interrogation of these associations may have potential diagnostic significance and may identify novel therapeutic avenues. Glycomics may also be a potent source of biomarkers of endometriosis, with a number of glyco-biomarkers already approved by the FDA. Endometriosis-associated microbial and glycomic profiles may represent viable targets for development of innovative diagnostics in this debilitating disease.

Citing Articles

Unveiling the Mechanisms of Pain in Endometriosis: Comprehensive Analysis of Inflammatory Sensitization and Therapeutic Potential.

Chen Y, Li T Int J Mol Sci. 2025; 26(4).

PMID: 40004233 PMC: 11855056. DOI: 10.3390/ijms26041770.

A Comprehensive Review of Advanced Diagnostic Techniques for Endometriosis: New Approaches to Improving Women's Well-Being.

Kaspute G, Bareikiene E, Prentice U, Uzieliene I, Ramasauskaite D, Ivaskiene T Medicina (Kaunas). 2024; 60(11).

PMID: 39597051 PMC: 11596456. DOI: 10.3390/medicina60111866.

Causal Link between Gut Microbiota and Infertility: A Two-sample Bidirectional Mendelian Randomization Study.

Zhang J, Li Q, Wang X, Zhang C, Chen S, Liu X Curr Med Sci. 2024; 44(6):1312-1324.

PMID: 39551855 DOI: 10.1007/s11596-024-2931-x.

Endometriosis specific vaginal microbiota links to urine and serum N-glycome.

MacSharry J, Kovacs Z, Xie Y, Adamczyk B, Walsh C, Reidy F Sci Rep. 2024; 14(1):25372.

PMID: 39455640 PMC: 11511964. DOI: 10.1038/s41598-024-76125-2.

Correlation between dysbiosis of vaginal microecology and endometriosis: A systematic review and meta-analysis.

Qing X, Xie M, Liu P, Feng O, Leng H, Guo H PLoS One. 2024; 19(7):e0306780.

PMID: 38976704 PMC: 11230536. DOI: 10.1371/journal.pone.0306780.

References

Bersinger N, Birkhauser M, Yared M, Wunder D . Serum glycodelin pattern during the menstrual cycle in healthy young women. Acta Obstet Gynecol Scand. 2009; 88(11):1215-21. DOI: 10.3109/00016340903294264. View

Piva M, Moreno J, Sharpe-Timms K . Glycosylation and over-expression of endometriosis-associated peritoneal haptoglobin. Glycoconj J. 2003; 19(1):33-41. DOI: 10.1023/a:1022580813870. View

Lamont R, Sobel J, Akins R, Hassan S, Chaiworapongsa T, Kusanovic J . The vaginal microbiome: new information about genital tract flora using molecular based techniques. BJOG. 2011; 118(5):533-49. PMC: 3055920. DOI: 10.1111/j.1471-0528.2010.02840.x. View

Saba L, Sulcis R, Melis G, De Cecco C, Laghi A, Piga M . Endometriosis: the role of magnetic resonance imaging. Acta Radiol. 2014; 56(3):355-67. DOI: 10.1177/0284185114526086. View

Khan K, Kitajima M, Hiraki K, Yamaguchi N, Katamine S, Matsuyama T . Escherichia coli contamination of menstrual blood and effect of bacterial endotoxin on endometriosis. Fertil Steril. 2010; 94(7):2860-3.e1-3. DOI: 10.1016/j.fertnstert.2010.04.053. View

Chen L, Fan R, Huang X, Xu H, Zhang X . Reduced levels of serum pigment epithelium-derived factor in women with endometriosis. Reprod Sci. 2011; 19(1):64-9. DOI: 10.1177/1933719111413300. View

Jones C, Inuwa I, Nardo L, Litta P, Fazleabas A . Eutopic endometrium from women with endometriosis shows altered ultrastructure and glycosylation compared to that from healthy controls--a pilot observational study. Reprod Sci. 2009; 16(6):559-72. PMC: 5098404. DOI: 10.1177/1933719109332825. View

Smarr M, Kannan K, Buck Louis G . Endocrine disrupting chemicals and endometriosis. Fertil Steril. 2016; 106(4):959-66. DOI: 10.1016/j.fertnstert.2016.06.034. View

Fassbender A, Burney R, F O D, DHooghe T, Giudice L . Update on Biomarkers for the Detection of Endometriosis. Biomed Res Int. 2015; 2015:130854. PMC: 4512573. DOI: 10.1155/2015/130854. View

10.

Kwa M, Plottel C, Blaser M, Adams S . The Intestinal Microbiome and Estrogen Receptor-Positive Female Breast Cancer. J Natl Cancer Inst. 2016; 108(8). PMC: 5017946. DOI: 10.1093/jnci/djw029. View

11.

Baston J, Baranao R, Ricci A, Bilotas M, Olivares C, Singla J . Targeting galectin-1-induced angiogenesis mitigates the severity of endometriosis. J Pathol. 2014; 234(3):329-37. DOI: 10.1002/path.4397. View

12.

Hadfield R, Mardon H, Barlow D, Kennedy S . Endometriosis in monozygotic twins. Fertil Steril. 1997; 68(5):941-2. DOI: 10.1016/s0015-0282(97)00359-2. View

13.

Hirsch M, Duffy J, Davis C, Nieves Plana M, Khan K . Diagnostic accuracy of cancer antigen 125 for endometriosis: a systematic review and meta-analysis. BJOG. 2016; 123(11):1761-8. DOI: 10.1111/1471-0528.14055. View

14.

Gupta D, Hull M, Fraser I, Miller L, Bossuyt P, Johnson N . Endometrial biomarkers for the non-invasive diagnosis of endometriosis. Cochrane Database Syst Rev. 2016; 4:CD012165. PMC: 6953323. DOI: 10.1002/14651858.CD012165. View

15.

Borghese B, Sibiude J, Santulli P, Lafay Pillet M, Marcellin L, Brosens I . Low birth weight is strongly associated with the risk of deep infiltrating endometriosis: results of a 743 case-control study. PLoS One. 2015; 10(2):e0117387. PMC: 4332485. DOI: 10.1371/journal.pone.0117387. View

16.

Xu B, Guo N, Zhang X, Shi W, Tong X, Iqbal F . Oocyte quality is decreased in women with minimal or mild endometriosis. Sci Rep. 2015; 5:10779. PMC: 4448226. DOI: 10.1038/srep10779. View

17.

Vodolazkaia A, Yesilyurt B, Kyama C, Bokor A, Schols D, Huskens D . Vascular endothelial growth factor pathway in endometriosis: genetic variants and plasma biomarkers. Fertil Steril. 2016; 105(4):988-96. DOI: 10.1016/j.fertnstert.2015.12.016. View

18.

Bottoni P, Scatena R . The Role of CA 125 as Tumor Marker: Biochemical and Clinical Aspects. Adv Exp Med Biol. 2015; 867:229-44. DOI: 10.1007/978-94-017-7215-0_14. View

19.

Von Theobald P, Cottenet J, Iacobelli S, Quantin C . Epidemiology of Endometriosis in France: A Large, Nation-Wide Study Based on Hospital Discharge Data. Biomed Res Int. 2016; 2016:3260952. PMC: 4842348. DOI: 10.1155/2016/3260952. View

20.

Gajbhiye R, Bendigeri T, Ghuge A, Bhusane K, Begum S, Warty N . Panel of Autoimmune Markers for Noninvasive Diagnosis of Minimal-Mild Endometriosis. Reprod Sci. 2016; 24(3):413-420. DOI: 10.1177/1933719116657190. View