Clinical Importance of Wnt5a in the Pathogenesis of Colorectal Cancer

Overview

Journal J Oncol

Specialty Oncology

Date 2021 Oct 4

PMID 34603445

Citations 2

Authors

Mehran Pashirzad

Thozhukat Sathyapalan

Amirhossein Sahebkar

Affiliations

Soon will be listed here.

Abstract

Wnt5a is one of the potent signaling molecules that initiates responses involved in cancer through activation of both canonical and noncanonical signaling cascades. Wnt5a both directly and indirectly triggers cancer-associated signaling pathways based on the cancer type. In colorectal cancer (CRC), altering Wnt5a expression can influence several cellular processes of tumor cells, including proliferation, differentiation, migration, invasion, and metastasis. This review summarizes the molecular mechanisms and clinical importance of Wnt5a in the pathogenesis of CRC for better understanding the pathogenesis and its potential role as a prognostic marker and as an appropriate therapeutic target in the treatment of this disease in the future.

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