Recurrent Rewiring of the Adult Hippocampal Mossy Fiber System by a Single Transcriptional Regulator, Id2

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 2021 Oct 2

PMID 34599103

Citations 8

Authors

Wenshu Luo

Matteo Egger

Andor Domonkos

Lin Que

David Lukacsovich

Natalia Andrea Cruz-Ochoa

Szilard Szocs

Charlotte Seng

Antonia Arszovszki

Eszter Sipos

Irmgard Amrein

Jochen Winterer

Tamas Lukacsovich

Janos Szabadics

David P Wolfer

Csaba Varga

Csaba Foldy

Affiliations

Soon will be listed here.

Abstract

Circuit formation in the central nervous system has been historically studied during development, after which cell-autonomous and nonautonomous wiring factors inactivate. In principle, balanced reactivation of such factors could enable further wiring in adults, but their relative contributions may be circuit dependent and are largely unknown. Here, we investigated hippocampal mossy fiber sprouting to gain insight into wiring mechanisms in mature circuits. We found that sole ectopic expression of Id2 in granule cells is capable of driving mossy fiber sprouting in healthy adult mouse and rat. Mice with the new mossy fiber circuit solved spatial problems equally well as controls but appeared to rely on local rather than global spatial cues. Our results demonstrate reprogrammed connectivity in mature neurons by one defined factor and an assembly of a new synaptic circuit in adult brain.

Citing Articles

Activation of feedforward wiring in adult hippocampal neurons by the basic-helix-loop-helix transcription factor Ascl4.

Luo W, Egger M, Cruz-Ochoa N, Tse A, Maloveczky G, Tamas B PNAS Nexus. 2024; 3(5):pgae174.

PMID: 38711810 PMC: 11071515. DOI: 10.1093/pnasnexus/pgae174.

Gephyrin phosphorylation facilitates sexually dimorphic development and function of parvalbumin interneurons in the mouse hippocampus.

Campbell B, Cruz-Ochoa N, Otomo K, Lukacsovich D, Espinosa P, Abegg A Mol Psychiatry. 2024; 29(8):2510-2526.

PMID: 38503929 PMC: 11412903. DOI: 10.1038/s41380-024-02517-5.

Commissural dentate granule cell projections and their rapid formation in the adult brain.

Egger M, Luo W, Cruz-Ochoa N, Lukacsovich D, Varga C, Que L PNAS Nexus. 2023; 2(4):pgad088.

PMID: 37077887 PMC: 10109062. DOI: 10.1093/pnasnexus/pgad088.

Marosi E, Arszovszki A, Brunner J, Szabadics J eNeuro. 2023; 10(2).

PMID: 36697256 PMC: 9907395. DOI: 10.1523/ENEURO.0017-23.2023.

Loss of enhances hippocampal excitability and epileptogenesis in mouse models of Smith-Magenis syndrome.

Chang Y, Kowalczyk M, Fogerson P, Lee Y, Haque M, Adams E Proc Natl Acad Sci U S A. 2022; 119(43):e2210122119.

PMID: 36256819 PMC: 9618093. DOI: 10.1073/pnas.2210122119.

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