The Nature of Blast Cells in Myelodysplastic Syndromes Evolving to Acute Leukaemia

Overview

Journal Blut

Specialty Hematology

Date 1986 Jun 1

PMID 3459562

Citations 1

Authors

J F San Miguel

M Gonzalez

M C Canizo

J P Anta

J Hernandez

F Ortega

L Borrasca

Affiliations

Soon will be listed here.

Abstract

The blast cells from nine patients with an overt acute leukaemia following a previous myelodysplastic syndrome (MDS) are analyzed with a panel of monoclonal antibodies as well as by morphological and cytochemical criteria. By integrating the results obtained with these three approaches the leukaemia in 6 patients was assessed as myeloid-granulocytic and/or monocytic-, in two as mixed- megakaryoblastic/myeloid- and in one as lymphoid. A good correlation between morphology, cytochemistry and immunological markers was observed in 7 out of the 9 cases. In three cases a noteworthy percentage of J5+ cells was detected. The exceptional finding of lymphoid as well as megakaryocytic and myeloid transformations suggests that the target cell for these leukaemias could be a pluripotent stem cell.

Citing Articles

Transformation of myelodysplastic syndrome to acute lymphoblastic leukemia: a case report and review of the literature.

Sato N, Nakazato T, Kizaki M, Ikeda Y, Okamoto S Int J Hematol. 2004; 79(2):147-51.

PMID: 15005342 DOI: 10.1532/ijh97.03137.

References

Schlossman S, Chess L, Humphreys R, Strominger J . Distribution of Ia-like molecules on the surface of normal and leukemic human cells. Proc Natl Acad Sci U S A. 1976; 73(4):1288-92. PMC: 430249. DOI: 10.1073/pnas.73.4.1288. View

Todd 3rd R, Nadler L, Schlossman S . Antigens on human monocytes identified by monoclonal antibodies. J Immunol. 1981; 126(4):1435-42. View

Ost A, Christensson B, Andreasen R, Hast R, LAGERLOF B, Reizenstein P . Immune phenotype heterogeneity in AML. Scand J Haematol. 1985; 34(4):293-302. DOI: 10.1111/j.1600-0609.1985.tb00751.x. View

Vainchenker W, Deschamps J, Bastin J, Guichard J, Titeux M, BRETON-GORIUS J . Two monoclonal antiplatelet antibodies as markers of human megakaryocyte maturation: immunofluorescent staining and platelet peroxidase detection in megakaryocyte colonies and in in vivo cells from normal and leukemic patients. Blood. 1982; 59(3):514-21. View

Zola H, McNamara P, Beckman I, Brooks D, Macardle P, Bradley J . Monoclonal antibodies against antigens of the human platelet surface: preparation and properties. Pathology. 1984; 16(1):73-8. DOI: 10.3109/00313028409067914. View

Tricot G, Boogaerts M, De Wolf-Peeters C, Van Den Berghe H, Verwilghen R . The myelodysplastic syndromes: different evolution patterns based on sequential morphological and cytogenetic investigations. Br J Haematol. 1985; 59(4):659-70. DOI: 10.1111/j.1365-2141.1985.tb07361.x. View

Hayhoe F, Quaglino D . Refractory sideroblastic anaemia and erythraemic myelosis: possible relationship and cytochemical observations. Br J Haematol. 1960; 6:381-7. DOI: 10.1111/j.1365-2141.1960.tb06256.x. View

Bennett J, Catovsky D, Daniel M, Flandrin G, GALTON D, Gralnick H . Proposals for the classification of the acute leukaemias. French-American-British (FAB) co-operative group. Br J Haematol. 1976; 33(4):451-8. DOI: 10.1111/j.1365-2141.1976.tb03563.x. View

Brooks D, Bradley J, Zola H . A differentiation antigen expressed selectively by a proportion of human blood cells: detection with a monoclonal antibody. Pathology. 1982; 14(1):5-11. DOI: 10.3109/00313028209069036. View

10.

Edwards P . Monoclonal antibodies that bind to the human erythrocyte-membrane glycoproteins glycophorin A and Band 3 [proceedings]. Biochem Soc Trans. 1980; 8(3):334-5. DOI: 10.1042/bst0080334. View

11.

Hehlmann R, Zonnchen B, Thiel E, Walther B . Idiopathic refractory sideroachrestic anemia (IRSA) progressing to acute mixed lymphoblastic-myelomonoblastic leukemia. Case report and review of the literature. Blut. 1983; 46(1):11-21. DOI: 10.1007/BF00320001. View

12.

Griffin J, Ritz J, Nadler L, Schlossman S . Expression of myeloid differentiation antigens on normal and malignant myeloid cells. J Clin Invest. 1981; 68(4):932-41. PMC: 370880. DOI: 10.1172/jci110348. View

13.

Breard J, Reinherz E, Kung P, Goldstein G, Schlossman S . A monoclonal antibody reactive with human peripheral blood monocytes. J Immunol. 1980; 124(4):1943-8. View

14.

Reinherz E, Kung P, Goldstein G, Levey R, Schlossman S . Discrete stages of human intrathymic differentiation: analysis of normal thymocytes and leukemic lymphoblasts of T-cell lineage. Proc Natl Acad Sci U S A. 1980; 77(3):1588-92. PMC: 348542. DOI: 10.1073/pnas.77.3.1588. View

15.

Majdic O, Bettelheim P, Stockinger H, Aberer W, Liszka K, Lutz D . M2, a novel myelomonocytic cell surface antigen and its distribution on leukemic cells. Int J Cancer. 1984; 33(5):617-23. DOI: 10.1002/ijc.2910330511. View

16.

Tricot G, Vlietinck R, Boogaerts M, Hendrickx B, De Wolf-Peeters C, Van Den Berghe H . Prognostic factors in the myelodysplastic syndromes: importance of initial data on peripheral blood counts, bone marrow cytology, trephine biopsy and chromosomal analysis. Br J Haematol. 1985; 60(1):19-32. DOI: 10.1111/j.1365-2141.1985.tb07381.x. View

17.

Berneman Z, Van Bockstaele D, De Meyer P, Van der Planken M, Vertessen F, De Bock R . A myelodysplastic syndrome preceding acute lymphoblastic leukaemia. Br J Haematol. 1985; 60(2):353-4. DOI: 10.1111/j.1365-2141.1985.tb07421.x. View

18.

San Miguel J, Tavares de Castro J, Matutes E, Rodriguez B, Polli N, Zola H . Characterization of blast cells in chronic granulocytic leukaemia in transformation, acute myelofibrosis and undifferentiated leukaemia. II. Studies with monoclonal antibodies and terminal transferase. Br J Haematol. 1985; 59(2):297-309. DOI: 10.1111/j.1365-2141.1985.tb02995.x. View

19.

Eridani S, Chan L, Halil O, Pearson T . Acute biphenotypic leukaemia (myeloid and null-ALL type) supervening in a myelodysplastic syndrome. Br J Haematol. 1985; 61(3):525-9. DOI: 10.1111/j.1365-2141.1985.tb02857.x. View

20.

Bennett J, Catovsky D, Daniel M, Flandrin G, GALTON D, Gralnick H . Proposals for the classification of the myelodysplastic syndromes. Br J Haematol. 1982; 51(2):189-99. View