Endothelial Dysfunction in Hematopoietic Cell Transplantation

Overview

Journal Clin Hematol Int

Specialty Hematology

Date 2021 Oct 1

PMID 34595410

Citations 13

Authors

Marta Palomo

Maribel Diaz-Ricart

Enric Carreras

Affiliations

Soon will be listed here.

Abstract

The goal of this review is to look at the role of endothelial damage and dysfunction in the initiation and development of early complications that appear after hematopoietic cell transplantation (HCT). These early complications share overlapping clinical manifestations and the suspicion of underlying endothelial damage. Several studies using different approaches, such as animal and in vitro models, the analysis of soluble biomarkers and clinical findings have provided evidence of this endothelial dysfunction. Historically, the first complication in which the role of endothelial damage was elucidated was the veno-oclusive disease/sinusoidal obstructive syndrome. In the last two decades, increasing evidence of the implication of the endothelium in the pathophysiology of other syndromes such as capillary leak syndrome, transplant-associated microangiopathy, or even graft host disease has accumulated. This knowledge opens up potential pharmacologic interventions to prevent/and/or treat endothelial damage and, therefore, to improve the outcome of patients receiving HCT.

Citing Articles

Safety and efficacy of G-CSF after allogeneic hematopoietic cell transplantation using post-transplant cyclophosphamide: clinical and in vitro examination of endothelial activation.

Escribano-Serrat S, Pedraza A, Suarez-Lledo M, Charry P, De Moner B, Martinez-Sanchez J Bone Marrow Transplant. 2024; 59(10):1466-1476.

PMID: 39117736 DOI: 10.1038/s41409-024-02388-y.

EASIX and cardiac adverse events after allogeneic hematopoietic cell transplantation.

Tolosa-Ridao C, Cascos E, Rodriguez-Lobato L, Pedraza A, Suarez-Lledo M, Charry P Bone Marrow Transplant. 2024; 59(7):974-982.

PMID: 38521885 DOI: 10.1038/s41409-024-02270-x.

Autotaxin is a potential predictive marker for the development of veno-occlusive disease/sinusoidal obstruction syndrome after allogeneic hematopoietic cell transplantation.

Takemura K, Nakamae M, Okamura H, Sakatoku K, Ido K, Makuuchi Y Ann Hematol. 2024; 103(5):1705-1715.

PMID: 38494552 DOI: 10.1007/s00277-024-05685-0.

Endothelial activation and damage as a common pathological substrate in different pathologies and cell therapy complications.

Palomo M, Moreno-Castano A, Salas M, Escribano-Serrat S, Rovira M, Guillen-Olmos E Front Med (Lausanne). 2023; 10:1285898.

PMID: 38034541 PMC: 10682735. DOI: 10.3389/fmed.2023.1285898.

Low Plasma Levels of Hyaluronic Acid Might Rule Out Sinusoidal Obstruction Syndrome after Hematopoietic Stem Cell Transplantation.

de Ramon Ortiz C, Justo Sanz R, Beauverd Y, Humala K, Lopez de la Guia A, de Paz R Dis Markers. 2023; 2023:7589017.

PMID: 37101837 PMC: 10125768. DOI: 10.1155/2023/7589017.

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