The Multifaceted Role of Lemur Tyrosine Kinase 3 in Health and Disease

Overview

Journal Open Biol

Specialties Biology
Cell Biology
Molecular Biology

Date 2021 Sep 28

PMID 34582708

Citations 6

Authors

Angeliki Ditsiou

Teresa Gagliano

Mark Samuels

Viviana Vella

Christos Tolias

Georgios Giamas

Affiliations

Soon will be listed here.

Abstract

In the last decade, LMTK3 (lemur tyrosine kinase 3) has emerged as an important player in breast cancer, contributing to the advancement of disease and the acquisition of resistance to therapy through a strikingly complex set of mechanisms. Although the knowledge of its physiological function is largely limited to receptor trafficking in neurons, there is mounting evidence that LMTK3 promotes oncogenesis in a wide variety of cancers. Recent studies have broadened our understanding of LMTK3 and demonstrated its importance in numerous signalling pathways, culminating in the identification of a potent and selective LMTK3 inhibitor. Here, we review the roles of LMTK3 in health and disease and discuss how this research may be used to develop novel therapeutics to advance cancer treatment.

Citing Articles

Targeting LMTK3 in ovarian cancer: A dual role in prognosis and therapy.

Filippopoulou C, Giamas G Mol Ther Oncol. 2024; 32(4):200902.

PMID: 39640864 PMC: 11617670. DOI: 10.1016/j.omton.2024.200902.

Lemur tail kinase 3 serves as a predictor of patient outcomes and a target for the treatment of ovarian cancer.

Saed G, Fletcher N, Sharma H, Stenmark Tullberg A, Ittner E, Parris T Mol Ther Oncol. 2024; 32(3):200864.

PMID: 39290318 PMC: 11406030. DOI: 10.1016/j.omton.2024.200864.

Therapeutic advances of targeting receptor tyrosine kinases in cancer.

Tomuleasa C, Tigu A, Munteanu R, Moldovan C, Kegyes D, Onaciu A Signal Transduct Target Ther. 2024; 9(1):201.

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Identification of homer protein homolog 3 as a prognostic marker of colon adenocarcinoma.

Luo M, Zhao C, Zhao Y, Wang Y, Li P Heliyon. 2024; 10(13):e33344.

PMID: 39035486 PMC: 11259827. DOI: 10.1016/j.heliyon.2024.e33344.

A revised nomenclature for the lemur family of protein kinases.

Morotz G, Bradbury N, Caluseriu O, Hisanaga S, Miller C, Swiatecka-Urban A Commun Biol. 2024; 7(1):57.

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