Pluripoietin Alpha: a Second Human Hematopoietic Colony-stimulating Factor Produced by the Human Bladder Carcinoma Cell Line 5637

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 1986 Apr 1

PMID 3458209

Citations 17

Authors

J L GABRILOVE

K Welte

P Harris

E PLATZER

L Lu

E Levi

R Mertelsmann

M A Moore

Affiliations

Soon will be listed here.

Abstract

We have identified a factor constitutively produced by the human bladder carcinoma cell line 5637, which has the following capacities: to induce the differentiation of the human promyelocytic leukemic cell line HL-60; to induce the expression of chemotactic peptide receptors in leukemic cells as well as in normal peripheral blood granulocytes; to function as a chemoattractant for neutrophils as well as, under certain conditions, inhibiting their migration; to support the growth of eosinophil and granulocyte/macrophage progenitors, which is maximal when scored at day 14; and to support the growth of human mixed pluripotent progenitors and erythroid bursts from normal human bone marrow. This factor has a molecular size of 32 kDa by gel filtration and 16.5 kDa by NaDodSO4/PAGE. We have termed this factor pluripoietin alpha.

Citing Articles

Comparative effects in vivo of recombinant murine interleukin 3, natural murine colony-stimulating factor-1, and recombinant murine granulocyte-macrophage colony-stimulating factor on myelopoiesis in mice.

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