TB and SIV Coinfection; a Model for Evaluating Vaccine Strategies Against TB Reactivation in Asian Origin Cynomolgus Macaques: A Pilot Study Using BCG Vaccination

Overview

Journal Vaccines (Basel)

Date 2021 Sep 28

PMID 34579182

Citations 8

Authors

Andrew D White

Laura Sibley

Jennie Gullick

Charlotte Sarfas

Simon Clark

Zahra Fagrouch

Ernst Verschoor

Francisco J Salguero

Mike Dennis

Sally Sharpe

Affiliations

Soon will be listed here.

Abstract

This pilot study aimed to determine the utility of a cynomolgus macaque model of coinfection with simian immunodeficiency virus (SIV) for the assessment of vaccines designed to prevent reactivation of TB. Following infection caused by aerosol exposure to an ultralow dose of (M. tb), data trends indicated that subsequent coinfection with SIVmac32H perturbed control of M. tb infection as evidenced by the increased occurrence of progressive disease in this group, higher levels of pathology and increased frequency of progressive tuberculous granulomas in the lung. BCG vaccination led to improved control of TB-induced disease and lower viral load in comparison to unvaccinated coinfected animals. The M. tb-specific IFNγ response after exposure to M. tb, previously shown to be associated with bacterial burden, was lower in the BCG-vaccinated group than in the unvaccinated groups. Levels of CD4+ and CD8+ T cells decreased in coinfected animals, with counts recovering more quickly in the BCG-vaccinated group. This pilot study provides proof of concept to support the use of the model for evaluation of interventions against reactivated/exacerbated TB caused by human immunodeficiency virus (HIV) infection.

Citing Articles

-Specific HLA-E-Restricted T Cells Are Induced during Infection but Not after BCG Administration in Non-Human Primates and Humans.

Voogd L, van Wolfswinkel M, Satti I, White A, Dijkman K, Gela A Vaccines (Basel). 2024; 12(10).

PMID: 39460296 PMC: 11511431. DOI: 10.3390/vaccines12101129.

specific HLA-E restricted T cells are induced during infection but not after BCG administration in non-human primates and humans.

Voogd L, van Wolfswinkel M, Satti I, White A, Dijkman K, Gela A bioRxiv. 2024; .

PMID: 39253433 PMC: 11383316. DOI: 10.1101/2024.08.26.609630.

Comparative pathology of experimental pulmonary tuberculosis in animal models.

Hunter L, Ruedas-Torres I, Agullo-Ros I, Rayner E, Salguero F Front Vet Sci. 2023; 10:1264833.

PMID: 37901102 PMC: 10602689. DOI: 10.3389/fvets.2023.1264833.

Characterisation and development of histopathological lesions in a guinea pig model of infection.

Larenas-Munoz F, Ruedas-Torres I, Hunter L, Bird A, Agullo-Ros I, Winsbury R Front Vet Sci. 2023; 10:1264200.

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Surveillance of Daughter Micronodule Formation Is a Key Factor for Vaccine Evaluation Using Experimental Infection Models of Tuberculosis in Macaques.

Nogueira I, Catala M, White A, Sharpe S, Bechini J, Prats C Pathogens. 2023; 12(2).

PMID: 36839508 PMC: 9961649. DOI: 10.3390/pathogens12020236.

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