Diet in Intestinal Fibrosis: A Double-Edged Sword

Overview

Journal Nutrients

Date 2021 Sep 28

PMID 34579023

Citations 2

Authors

Rachel Marion-Letellier

Mathilde Leboutte

Asma Amamou

Maitreyi Raman

Guillaume Savoye

Subrata Ghosh

Affiliations

Soon will be listed here.

Abstract

The natural history of inflammatory bowel diseases, especially Crohn's disease, is frequently complicated by intestinal fibrosis. Because of the lack of effective treatments for intestinal fibrosis, there is an urgent need to develop new therapies. Factors promoting intestinal fibrosis are currently unclear, but diet is a potential culprit. Diet may influence predisposition to develop intestinal fibrosis or alter its natural history by modification of both the host immune response and intestinal microbial composition. Few studies have documented the effects of dietary factors in modulating IBD-induced intestinal fibrosis. As the mechanisms behind fibrogenesis in the gut are believed to be broadly similar to those from extra-intestinal organs, it may be relevant to investigate which dietary components can inhibit or promote fibrosis factors such as myofibroblasts progenitor activation in other fibrotic diseases.

Citing Articles

Inflammation accelerating intestinal fibrosis: from mechanism to clinic.

Xin S, Liu X, He C, Gao H, Wang B, Hua R Eur J Med Res. 2024; 29(1):335.

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The Role of Genetic and Epigenetic Regulation in Intestinal Fibrosis in Inflammatory Bowel Disease: A Descending Process or a Programmed Consequence?.

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