Non-Heating Alternating Magnetic Field Nanomechanical Stimulation of Biomolecule Structures Via Magnetic Nanoparticles As the Basis for Future Low-Toxic Biomedical Applications

Overview

Journal Nanomaterials (Basel)

Date 2021 Sep 28

PMID 34578570

Citations 7

Authors

Yuri I Golovin

Dmitry Yu Golovin

Ksenia Yu Vlasova

Maxim M Veselov

Azizbek D Usvaliev

Alexander V Kabanov

Natalia L Klyachko

Affiliations

Soon will be listed here.

Abstract

The review discusses the theoretical, experimental and toxicological aspects of the prospective biomedical application of functionalized magnetic nanoparticles (MNPs) activated by a low frequency non-heating alternating magnetic field (AMF). In this approach, known as nano-magnetomechanical activation (NMMA), the MNPs are used as mediators that localize and apply force to such target biomolecular structures as enzyme molecules, transport vesicles, cell organelles, etc., without significant heating. It is shown that NMMA can become a biophysical platform for a family of therapy methods including the addressed delivery and controlled release of therapeutic agents from transport nanomodules, as well as selective molecular nanoscale localized drugless nanomechanical impacts. It is characterized by low system biochemical and electromagnetic toxicity. A technique of 3D scanning of the NMMA region with the size of several mm to several cm over object internals has been described.

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