Efficacy of Needle-Less Intradermal Vaccination Against Porcine Epidemic Diarrhea Virus

Overview

Journal Pathogens

Date 2021 Sep 28

PMID 34578148

Citations 4

Authors

SeEun Choe

Gyu-Nam Park

Sok Song

Jihye Shin

Van Phan Le

Van Giap Nguyen

Ki-Sun Kim

Hye Kwon Kim

Bang-Hun Hyun

Dong-Jun An

Affiliations

Soon will be listed here.

Abstract

To prevent diarrhea in suckling piglets infected by porcine epidemic diarrhea virus (PEDV), porcine epidemic diarrhea (PED) vaccines are administered mainly through intramuscular (IM) or oral routes. We found that growing pigs vaccinated with an inactivated PEDV vaccine via the intradermal (ID) route had higher neutralizing antibody titers and cytokine (IFN-γ, IL-4, and IL-10) levels than non-vaccinated pigs. In addition, suckling piglets acquired lactogenic immunity from pregnant sows inoculated with an ID PED vaccine. We evaluated the efficacy of vaccination via this route, along with subsequent protection against virulent PEDV. At six days post-challenge, the survival rate of suckling piglets exposed to virulent PEDV was 70% for the ID group and 0% for the mock group (no vaccine). At necropsy, villi length in the duodenum and ileum of piglets with lactogenic immunity provided by ID-vaccinated sows proved to be significant ( < 0.05) when compared with those in piglets from mock group sows. Thus, vaccination using an inactivated PED vaccine via the ID route provides partial protection against infection by virulent PEDV.

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