Evaluating the Anticarcinogenic Activity of Surface Modified/Functionalized Nanochitosan: The Emerging Trends and Endeavors

Overview

Journal Polymers (Basel)

Publisher MDPI

Date 2021 Sep 28

PMID 34578039

Citations 2

Authors

Jae-Wook Oh

Juhyun Shin

Sechul Chun

Manikandan Muthu

Judy Gopal

Affiliations

Soon will be listed here.

Abstract

Chitosan begins its humble journey from marine food shell wastes and ends up as a versatile nutraceutical. This review focuses on briefly discussing the antioxidant activity of chitosan and retrospecting the accomplishments of chitosan nanoparticles as an anticarcinogen. The various modified/functionalized/encapsulated chitosan nanoparticles and nanoforms have been listed and their biomedical deliverables presented. The anticancer accomplishments of chitosan and its modified composites have been reviewed and presented. The future of surface modified chitosan and the lacunae in the current research focus have been discussed as future perspective. This review puts forth the urge to expand the scientific curiosity towards attempting a variety of functionalization and surface modifications to chitosan. There are few well known modifications and functionalization that benefit biomedical applications that have been proven for other systems. Being a biodegradable, biocompatible polymer, chitosan-based nanomaterials are an attractive option for medical applications. Therefore, maximizing expansion of its bioactive properties are explored. The need for applying the ideal functionalization that will significantly promote the anticancer contributions of chitosan nanomaterials has also been stressed.

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References

Park B, Kim M . Applications of chitin and its derivatives in biological medicine. Int J Mol Sci. 2011; 11(12):5152-64. PMC: 3100826. DOI: 10.3390/ijms11125152. View

Hwang H, Kim I, Kwon I, Kim Y . Tumor targetability and antitumor effect of docetaxel-loaded hydrophobically modified glycol chitosan nanoparticles. J Control Release. 2008; 128(1):23-31. DOI: 10.1016/j.jconrel.2008.02.003. View

Adhikari H, Nath Yadav P . Anticancer Activity of Chitosan, Chitosan Derivatives, and Their Mechanism of Action. Int J Biomater. 2019; 2018:2952085. PMC: 6332982. DOI: 10.1155/2018/2952085. View

Ramirez K, Wahid R, Richardson C, Bargatze R, El-Kamary S, Sztein M . Intranasal vaccination with an adjuvanted Norwalk virus-like particle vaccine elicits antigen-specific B memory responses in human adult volunteers. Clin Immunol. 2012; 144(2):98-108. DOI: 10.1016/j.clim.2012.05.006. View

Belabassi Y, Moreau J, Gheran V, Henoumont C, Robert A, Callewaert M . Synthesis and Characterization of PEGylated and Fluorinated Chitosans: Application to the Synthesis of Targeted Nanoparticles for Drug Delivery. Biomacromolecules. 2017; 18(9):2756-2766. DOI: 10.1021/acs.biomac.7b00668. View

Ways T, Lau W, Khutoryanskiy V . Chitosan and Its Derivatives for Application in Mucoadhesive Drug Delivery Systems. Polymers (Basel). 2019; 10(3). PMC: 6414903. DOI: 10.3390/polym10030267. View

Zhou Y, Yang H, Liu X, Mao J, Gu S, Xu W . Electrospinning of carboxyethyl chitosan/poly(vinyl alcohol)/silk fibroin nanoparticles for wound dressings. Int J Biol Macromol. 2012; 53:88-92. DOI: 10.1016/j.ijbiomac.2012.11.013. View

Li Z, Yang F, Yang R . Synthesis and characterization of chitosan derivatives with dual-antibacterial functional groups. Int J Biol Macromol. 2015; 75:378-87. DOI: 10.1016/j.ijbiomac.2015.01.056. View

Wang H, Mukherjee S, Yi J, Banerjee P, Chen Q, Zhou S . Biocompatible Chitosan-Carbon Dot Hybrid Nanogels for NIR-Imaging-Guided Synergistic Photothermal-Chemo Therapy. ACS Appl Mater Interfaces. 2017; 9(22):18639-18649. DOI: 10.1021/acsami.7b06062. View

10.

Almutairi F, Abd-Rabou A, Mohamed M . Raloxifene-encapsulated hyaluronic acid-decorated chitosan nanoparticles selectively induce apoptosis in lung cancer cells. Bioorg Med Chem. 2019; 27(8):1629-1638. DOI: 10.1016/j.bmc.2019.03.004. View

11.

Xu Y, Wen Z, Xu Z . Chitosan nanoparticles inhibit the growth of human hepatocellular carcinoma xenografts through an antiangiogenic mechanism. Anticancer Res. 2010; 29(12):5103-9. View

12.

Abbas Y, Azzazy H, Tammam S, Lamprecht A, Ali M, Schmidt A . Development of an inhalable, stimuli-responsive particulate system for delivery to deep lung tissue. Colloids Surf B Biointerfaces. 2016; 146:19-30. DOI: 10.1016/j.colsurfb.2016.05.031. View

13.

Nair R, Morris A, Billa N, Leong C . An Evaluation of Curcumin-Encapsulated Chitosan Nanoparticles for Transdermal Delivery. AAPS PharmSciTech. 2019; 20(2):69. DOI: 10.1208/s12249-018-1279-6. View

14.

Zhang H, Wu F, Li Y, Yang X, Huang J, Lv T . Chitosan-based nanoparticles for improved anticancer efficacy and bioavailability of mifepristone. Beilstein J Nanotechnol. 2017; 7:1861-1870. PMC: 5238647. DOI: 10.3762/bjnano.7.178. View

15.

Jiang Z, Han B, Li H, Yang Y, Liu W . Carboxymethyl chitosan represses tumor angiogenesis in vitro and in vivo. Carbohydr Polym. 2015; 129:1-8. DOI: 10.1016/j.carbpol.2015.04.040. View

16.

Vila A, Sanchez A, Janes K, Behrens I, Kissel T, Vila Jato J . Low molecular weight chitosan nanoparticles as new carriers for nasal vaccine delivery in mice. Eur J Pharm Biopharm. 2004; 57(1):123-31. DOI: 10.1016/j.ejpb.2003.09.006. View

17.

Zhou Y, Yang D, Chen X, Xu Q, Lu F, Nie J . Electrospun water-soluble carboxyethyl chitosan/poly(vinyl alcohol) nanofibrous membrane as potential wound dressing for skin regeneration. Biomacromolecules. 2007; 9(1):349-54. DOI: 10.1021/bm7009015. View

18.

Swierczewska M, Han H, Kim K, Park J, Lee S . Polysaccharide-based nanoparticles for theranostic nanomedicine. Adv Drug Deliv Rev. 2015; 99(Pt A):70-84. PMC: 4798864. DOI: 10.1016/j.addr.2015.11.015. View

19.

Dambies L, Vincent T, Domard A, Guibal E . Preparation of chitosan gel beads by ionotropic molybdate gelation. Biomacromolecules. 2002; 2(4):1198-205. DOI: 10.1021/bm010083r. View

20.

Chen H, Huang J, Yu J, Liu S, Gu P . Electrospun chitosan-graft-poly (ε -caprolactone)/poly (ε-caprolactone) cationic nanofibrous mats as potential scaffolds for skin tissue engineering. Int J Biol Macromol. 2010; 48(1):13-9. DOI: 10.1016/j.ijbiomac.2010.09.019. View