Gas Plasma-Augmented Wound Healing in Animal Models and Veterinary Medicine

Overview

Journal Molecules

Publisher MDPI

Specialty Biology

Date 2021 Sep 28

PMID 34577153

Citations 13

Authors

Sander Bekeschus

Axel Kramer

Anke Schmidt

Affiliations

Soon will be listed here.

Abstract

The loss of skin integrity is inevitable in life. Wound healing is a necessary sequence of events to reconstitute the body's integrity against potentially harmful environmental agents and restore homeostasis. Attempts to improve cutaneous wound healing are therefore as old as humanity itself. Furthermore, nowadays, targeting defective wound healing is of utmost importance in an aging society with underlying diseases such as diabetes and vascular insufficiencies being on the rise. Because chronic wounds' etiology and specific traits differ, there is widespread polypragmasia in targeting non-healing conditions. Reactive oxygen and nitrogen species (ROS/RNS) are an overarching theme accompanying wound healing and its biological stages. ROS are signaling agents generated by phagocytes to inactivate pathogens. Although ROS/RNS's central role in the biology of wound healing has long been appreciated, it was only until the recent decade that these agents were explicitly used to target defective wound healing using gas plasma technology. Gas plasma is a physical state of matter and is a partially ionized gas operated at body temperature which generates a plethora of ROS/RNS simultaneously in a spatiotemporally controlled manner. Animal models of wound healing have been vital in driving the development of these wound healing-promoting technologies, and this review summarizes the current knowledge and identifies open ends derived from in vivo wound models under gas plasma therapy. While gas plasma-assisted wound healing in humans has become well established in Europe, veterinary medicine is an emerging field with great potential to improve the lives of suffering animals.

Citing Articles

Biomimetic Hydrogels - Tools for Regenerative Medicine, Oncology, and Understanding Medical Gas Plasma Therapy.

Martinet A, Miebach L, Weltmann K, Emmert S, Bekeschus S Small. 2025; 21(9):e2403856.

PMID: 39905967 PMC: 11878268. DOI: 10.1002/smll.202403856.

Non-invasive physical plasma improves conventional wound management of cut and bite wounds in wild European hedgehogs.

Eichler J, Rulik B, Abazid A, Stope M Sci Rep. 2025; 15(1):2744.

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[Mechanism of cold atmospheric plasma in treatment of chronic skin ulcer].

Yuan N, Yang Y, Tan C, Ran X Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2024; 38(10):1283-1288.

PMID: 39433505 PMC: 11522536. DOI: 10.7507/1002-1892.202404027.

Proposing an Affordable Plasma Device for Polymer Surface Modification and Microbial Inactivation.

Chiappim W, Kodaira F, Castro G, Silva D, Tavares T, Almeida A Molecules. 2024; 29(17).

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Training in the use of the water jet and cold atmospheric plasma jet for the decontamination of dental implants.

Matthes R, Jablonowski L, Pitchika V, Holtfreter B, Eberhard C, Gerling T Clin Oral Investig. 2024; 28(6):355.

PMID: 38833072 PMC: 11150293. DOI: 10.1007/s00784-024-05749-5.

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