Non-Alkaloid Cholinesterase Inhibitory Compounds from Natural Sources

Overview

Journal Molecules

Publisher MDPI

Specialty Biology

Date 2021 Sep 28

PMID 34577053

Citations 17

Authors

Alfred Ngenge Tamfu

Selcuk Kucukaydin

Balakyz Yeskaliyeva

Mehmet Ozturk

Rodica Mihaela Dinica

Affiliations

Soon will be listed here.

Abstract

Alzheimer's disease (AD) is a severe neurodegenerative disorder of different brain regions accompanied by distresses and affecting more than 25 million people in the world. This progressive brain deterioration affects the central nervous system and has negative impacts on a patient's daily activities such as memory impairment. The most important challenge concerning AD is the development of new drugs for long-term treatment or prevention, with lesser side effects and greater efficiency as cholinesterases inhibitors and the ability to remove amyloid-beta(Aβ) deposits and other related AD neuropathologies. Natural sources provide promising alternatives to synthetic cholinesterase inhibitors and many have been reported for alkaloids while neglecting other classes with potential cholinesterase inhibition. This review summarizes information about the therapeutic potential of small natural molecules from medicinal herbs, belonging to terpenoids, coumarins, and phenolic compounds, and others, which have gained special attention due to their specific modes of action and their advantages of low toxicity and high efficiency in the treatment of AD. Some show superior drug-like features in comparison to synthetic cholinesterase inhibitors. We expect that the listed phytoconstituents in this review will serve as promising tools and chemical scaffolds for the discovery of new potent therapeutic leads for the amelioration and treatment of Alzheimer's disease.

Citing Articles

Cholinesterase Inhibitors from Plants and Their Potential in Alzheimer's Treatment: Systematic Review.

ALNasser M, Alboraiy G, Alsowig E, Alqattan F Brain Sci. 2025; 15(2).

PMID: 40002547 PMC: 11852592. DOI: 10.3390/brainsci15020215.

Biological Implications of the Intrinsic Deformability of Human Acetylcholinesterase Induced by Diverse Compounds: A Computational Study.

Alvarado Y, Gonzalez-Paz L, Paz J, Lorono-Gonzalez M, Santiago Contreras J, Lossada C Biology (Basel). 2025; 13(12.

PMID: 39765732 PMC: 11672903. DOI: 10.3390/biology13121065.

Evaluation of HPLC Profile, Antioxidant, Quorum Sensing, Biofilm, Swarming Motility, and Enzyme Inhibition Activities of Conventional and Green Extracts of .

Quradha M, Ngenge Tamfu A, Duru M, Kucukaydin S, Iqbal M, Qahtan A Food Sci Nutr. 2024; 12(12):10716-10733.

PMID: 39723056 PMC: 11666897. DOI: 10.1002/fsn3.4580.

Vegan and Vegetarian Soups Are Excellent Sources of Cholinesterase Inhibitors.

Gajowniczek-Alasa D, Baranowska-Wojcik E, Szwajgier D Nutrients. 2024; 16(13).

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In Vitro and Molecular Docking Evaluation of the Anticholinesterase and Antidiabetic Effects of Compounds from Guill. & Perr. (Combretaceae).

Feunaing R, Ngenge Tamfu A, Gbaweng A, Kucukaydin S, Tchamgoue J, Meli Lannang A Molecules. 2024; 29(11).

PMID: 38893333 PMC: 11174011. DOI: 10.3390/molecules29112456.

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