Antimicrobial, Antioxidant and Antiproliferative Secondary Metabolites from

Overview

Journal Molecules

Publisher MDPI

Specialty Biology

Date 2021 Sep 28

PMID 34576923

Citations 3

Authors

Zsofia Garadi

Miklos Dekany

Agnes M Moricz

Aniko Gaal

Viktor Papp

Szabolcs Beni

Attila Vanyolos

Affiliations

Soon will be listed here.

Abstract

is a sterile conk which produces macrofungus, a neglected Central-Eastern European relative of the prized , also known as chaga. Investigation of the methanol extract of the poroid fungus resulted in the isolation of citropremide (), 3,4-dihydroxybenzalacetone () , lanosterol (), ergost-6,8,22-trien-3β-ol (), and ergosterol peroxide (). The structures of fungal compounds were determined on the basis of one- and two-dimensional NMR and MS spectroscopic analysis. Compounds - and - were evaluated for their antioxidant and antimicrobial properties against several bacterial and fungal strains. 3,4-dihydroxybenzalacetone () and ergost-6,8,22-trien-3β-ol () demonstrated moderate antimicrobial activity, while the former possessed notable antioxidant activity in DPPH assay. The antiproliferative examinations performed on three human cancer (MES-SA, MES-SA/Dx5, A431) cell lines demonstrated that compounds and have notable cytotoxic activity with IC values in micromolar range. The current study represents the first report on the chemical profile of , providing a comprehensive study on the isolation and structure determination of bioactive secondary metabolites of this macrofungus.

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