Lipid Nanoparticle Technology for Delivering Biologically Active Fatty Acids and Monoglycerides

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2021 Sep 28

PMID 34575831

Citations 9

Authors

Jia Ying Brenda Tan

Bo Kyeong Yoon

Nam-Joon Cho

Jasmina Lovric

Mario Jug

Joshua A Jackman

Affiliations

Soon will be listed here.

Abstract

There is enormous interest in utilizing biologically active fatty acids and monoglycerides to treat phospholipid membrane-related medical diseases, especially with the global health importance of membrane-enveloped viruses and bacteria. However, it is difficult to practically deliver lipophilic fatty acids and monoglycerides for therapeutic applications, which has led to the emergence of lipid nanoparticle platforms that support molecular encapsulation and functional presentation. Herein, we introduce various classes of lipid nanoparticle technology and critically examine the latest progress in utilizing lipid nanoparticles to deliver fatty acids and monoglycerides in order to treat medical diseases related to infectious pathogens, cancer, and inflammation. Particular emphasis is placed on understanding how nanoparticle structure is related to biological function in terms of mechanism, potency, selectivity, and targeting. We also discuss translational opportunities and regulatory needs for utilizing lipid nanoparticles to deliver fatty acids and monoglycerides, including unmet clinical opportunities.

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References

Jackman J, Meszaros T, Fulop T, Urbanics R, Szebeni J, Cho N . Comparison of complement activation-related pseudoallergy in miniature and domestic pigs: foundation of a validatable immune toxicity model. Nanomedicine. 2016; 12(4):933-943. DOI: 10.1016/j.nano.2015.12.377. View

Zhdanov V, Jackman J . Analysis of the initiation of viral infection under flow conditions with applications to transmission in feed. Biosystems. 2020; 196:104184. PMC: 7282798. DOI: 10.1016/j.biosystems.2020.104184. View

Calder P, Waitzberg D, Klek S, Martindale R . Lipids in Parenteral Nutrition: Biological Aspects. JPEN J Parenter Enteral Nutr. 2020; 44 Suppl 1:S21-S27. DOI: 10.1002/jpen.1756. View

Das U . Can Bioactive Lipids Inactivate Coronavirus (COVID-19)?. Arch Med Res. 2020; 51(3):282-286. PMC: 7270578. DOI: 10.1016/j.arcmed.2020.03.004. View

Yoon B, Jeon W, Sut T, Cho N, Jackman J . Stopping Membrane-Enveloped Viruses with Nanotechnology Strategies: Toward Antiviral Drug Development and Pandemic Preparedness. ACS Nano. 2020; 15(1):125-148. DOI: 10.1021/acsnano.0c07489. View

Brunaldi K, Huang N, Hamilton J . Fatty acids are rapidly delivered to and extracted from membranes by methyl-beta-cyclodextrin. J Lipid Res. 2009; 51(1):120-31. PMC: 2789772. DOI: 10.1194/M900200-JLR200. View

Seabra C, Nunes C, Gomez-Lazaro M, Correia M, Machado J, Goncalves I . Docosahexaenoic acid loaded lipid nanoparticles with bactericidal activity against Helicobacter pylori. Int J Pharm. 2017; 519(1-2):128-137. DOI: 10.1016/j.ijpharm.2017.01.014. View

Mitchell M, Billingsley M, Haley R, Wechsler M, Peppas N, Langer R . Engineering precision nanoparticles for drug delivery. Nat Rev Drug Discov. 2020; 20(2):101-124. PMC: 7717100. DOI: 10.1038/s41573-020-0090-8. View

Ribeiro L, de Paula E, Rossi D, Martins F, de Melo R, Monteiro G . Nanocarriers From Natural Lipids With Activity Against . Front Cell Infect Microbiol. 2021; 10:571040. PMC: 7820125. DOI: 10.3389/fcimb.2020.571040. View

10.

Yoon B, Park S, Ma G, Kolahdouzan K, Zhdanov V, Jackman J . Competing Interactions of Fatty Acids and Monoglycerides Trigger Synergistic Phospholipid Membrane Remodeling. J Phys Chem Lett. 2020; 11(13):4951-4957. DOI: 10.1021/acs.jpclett.0c01138. View

11.

Tran T, Hsieh M, Chang K, Pho Q, Nguyen V, Cheng C . Bactericidal Effect of Lauric Acid-Loaded PCL-PEG-PCL Nano-Sized Micelles on Skin Commensal Propionibacterium acnes. Polymers (Basel). 2019; 8(9). PMC: 6431869. DOI: 10.3390/polym8090321. View

12.

Mohamed Z, Shin J, Ghosh S, Sharma A, Pinnock F, Bint E Naser Farnush S . Clinically Relevant Bacterial Outer Membrane Models for Antibiotic Screening Applications. ACS Infect Dis. 2021; 7(9):2707-2722. DOI: 10.1021/acsinfecdis.1c00217. View

13.

Shetab Boushehri M, Dietrich D, Lamprecht A . Nanotechnology as a Platform for the Development of Injectable Parenteral Formulations: A Comprehensive Review of the Know-Hows and State of the Art. Pharmaceutics. 2020; 12(6). PMC: 7356945. DOI: 10.3390/pharmaceutics12060510. View

14.

Huang W, Tsai T, Chuang L, Li Y, Zouboulis C, Tsai P . Anti-bacterial and anti-inflammatory properties of capric acid against Propionibacterium acnes: a comparative study with lauric acid. J Dermatol Sci. 2013; 73(3):232-40. DOI: 10.1016/j.jdermsci.2013.10.010. View

15.

Chang H, Yeh M . Clinical development of liposome-based drugs: formulation, characterization, and therapeutic efficacy. Int J Nanomedicine. 2012; 7:49-60. PMC: 3260950. DOI: 10.2147/IJN.S26766. View

16.

Igyarto B, Jacobsen S, Ndeupen S . Future considerations for the mRNA-lipid nanoparticle vaccine platform. Curr Opin Virol. 2021; 48:65-72. PMC: 8065267. DOI: 10.1016/j.coviro.2021.03.008. View

17.

Churchward C, Alany R, Kirk R, Walker A, Snyder L . Prevention of Ophthalmia Neonatorum Caused by Using a Fatty Acid-Based Formulation. mBio. 2017; 8(4). PMC: 5527305. DOI: 10.1128/mBio.00534-17. View

18.

Pepic I, Lovric J, Cetina-cizmek B, Reichl S, Filipovic-Grcic J . Toward the practical implementation of eye-related bioavailability prediction models. Drug Discov Today. 2013; 19(1):31-44. DOI: 10.1016/j.drudis.2013.08.002. View

19.

Rozenbaum R, Su L, Umerska A, Eveillard M, Hakansson J, Mahlapuu M . Antimicrobial synergy of monolaurin lipid nanocapsules with adsorbed antimicrobial peptides against Staphylococcus aureus biofilms in vitro is absent in vivo. J Control Release. 2018; 293:73-83. DOI: 10.1016/j.jconrel.2018.11.018. View

20.

Guo P, Si M, Wu D, Xue H, Hu W, Wong H . Incorporation of docosahexaenoic acid (DHA) enhances nanodelivery of antiretroviral across the blood-brain barrier for treatment of HIV reservoir in brain. J Control Release. 2020; 328:696-709. PMC: 7749038. DOI: 10.1016/j.jconrel.2020.09.050. View