MicroRNAs-The Heart of Post-Myocardial Infarction Remodeling

Overview

Journal Diagnostics (Basel)

Specialty Radiology

Date 2021 Sep 28

PMID 34574016

Citations 12

Authors

Liana Maries

Catalin Marian

Raluca Sosdean

Flavia Goanta

Ioan Ovidiu Sirbu

Andrei Anghel

Affiliations

Soon will be listed here.

Abstract

Myocardial infarction (MI) is one of the most frequent cardiac emergencies, with significant potential for mortality. One of the major challenges of the post-MI healing response is that replacement fibrosis could lead to left ventricular remodeling (LVR) and heart failure (HF). This process involves canonical and non-canonical transforming growth factor-beta (TGF-β) signaling pathways translating into an intricate activation of cardiac fibroblasts and disproportionate collagen synthesis. Accumulating evidence has indicated that microRNAs (miRNAs) significantly contribute to the modulation of these signaling pathways. This review summarizes the recent updates regarding the molecular mechanisms underlying the role of the over 30 miRNAs involved in post-MI LVR. In addition, we compare the contradictory roles of several multifunctional miRNAs and highlight their potential use in pressure overload and ischemia-induced fibrosis. Finally, we discuss their attractive role as prognostic biomarkers for HF, highlighting the most relevant human trials involving these miRNAs.

Citing Articles

Circulating microRNA-409-5p and USP7 are associated with left ventricular remodeling in patients with acute myocardial infarction.

He G, Sha S, He J, Zhang X, Jin Q, Zhao T BMC Cardiovasc Disord. 2024; 24(1):615.

PMID: 39488705 PMC: 11531163. DOI: 10.1186/s12872-024-04299-8.

MicroRNA-1 Deficiency Is a Primary Etiological Factor Disrupting Cardiac Contractility and Electrophysiological Homeostasis.

Yang D, Wan X, Schwieterman N, Cavus O, Kacira E, Xu X Circ Arrhythm Electrophysiol. 2023; 17(1):e012150.

PMID: 38126205 PMC: 10842700. DOI: 10.1161/CIRCEP.123.012150.

MicroRNA-30d-5p-A Potential New Therapeutic Target for Prevention of Ischemic Cardiomyopathy after Myocardial Infarction.

Boxhammer E, Paar V, Wernly B, Kiss A, Mirna M, Aigner A Cells. 2023; 12(19).

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Functional evaluation of constructed pseudo-endogenous microRNA-targeted myocardial ultrasound nanobubble.

Ainiwan A, Wei Y, Dou J, Tang L, Mu Y, Guan L Front Med (Lausanne). 2023; 10:1136304.

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Plasma hsa-miR-22-3p Might Serve as an Early Predictor of Ventricular Function Recovery after ST-Elevation Acute Myocardial Infarction.

Maries L, Moatar A, Chis A, Marian C, Luca C, Sirbu I Biomedicines. 2023; 11(8).

PMID: 37626785 PMC: 10452683. DOI: 10.3390/biomedicines11082289.

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