Supplementary Tryptophan Fed to Sows Prior to and After Farrowing to Improve Piglet Growth and Survival

Overview

Journal Animals (Basel)

Date 2021 Sep 28

PMID 34573506

Citations 2

Authors

Amy L Munn

Alice C Weaver

William H E J van Wettere

Affiliations

Soon will be listed here.

Abstract

Tryptophan indirectly increases plasma calcium levels, which may improve sow health, and melatonin production, which may improve piglet survival when supplemented during late gestation and lactation. It was hypothesised that tryptophan would increase piglet survival and increase sow circulating melatonin and calcium. Seventy-two multiparous (Landrace x Large White) sows were allocated to either control (0.16% tryptophan; = 24), low tryptophan (0.42%; = 24) or high tryptophan (0.56%; = 24). Piglet viability measures consisted of weights, behaviour, meconium staining, rectal temperature, blood glucose and serum immunoglobulin G concentration. Blood samples collected from sows were analysed for melatonin (two daytime and three night-time samples; = 17) and calcium (two samples pre- and post-farrowing; = 14). Both tryptophan treatments increased piglet survival compared to the control group ( < 0.001). Tryptophan had no effect on piglet viability ( > 0.05) and no effect on sow plasma melatonin and calcium concentrations compared with the control group ( > 0.05) except at 21:00 when low tryptophan sows had higher melatonin concentration compared with high tryptophan ( = 0.011). Further research to understand the mediating effects of tryptophan (particularly 5-hydroxytryptophan) on piglet survival, including sow behaviour, is warranted.

Citing Articles

Intestinal tryptophan metabolism in disease prevention and swine production.

Hu Z, Feng L, Jiang Q, Wang W, Tan B, Tang X Anim Nutr. 2023; 15:364-374.

PMID: 38058568 PMC: 10695851. DOI: 10.1016/j.aninu.2023.08.002.

The use of functional amino acids in different categories of pigs - A review.

Hodkovicova N, Halas S, Tosnerova K, Stastny K, Svoboda M Vet Med (Praha). 2023; 68(8):299-312.

PMID: 37982122 PMC: 10646542. DOI: 10.17221/72/2023-VETMED.

References

Poletto R, Kretzer F, Hotzel M . Minimizing aggression during mixing of gestating sows with supplementation of a tryptophan-enriched diet. Physiol Behav. 2014; 132:36-43. DOI: 10.1016/j.physbeh.2014.04.043. View

Thakor A, Herrera E, Seron-Ferre M, Giussani D . Melatonin and vitamin C increase umbilical blood flow via nitric oxide-dependent mechanisms. J Pineal Res. 2010; 49(4):399-406. DOI: 10.1111/j.1600-079X.2010.00813.x. View

Beaulieu A, Aalhus J, Williams N, Patience J . Impact of piglet birth weight, birth order, and litter size on subsequent growth performance, carcass quality, muscle composition, and eating quality of pork. J Anim Sci. 2010; 88(8):2767-78. DOI: 10.2527/jas.2009-2222. View

Greiner L, Neill C, Allee G, Touchette K, Connor J . Evaluation of the optimal standardized ileal digestible tryptophan:lysine ratio in lactating sow diets. Transl Anim Sci. 2020; 1(4):526-532. PMC: 7204970. DOI: 10.2527/tas2017.0059. View

Xu K, Bai M, Bin P, Duan Y, Wu X, Liu H . Negative effects on newborn piglets caused by excess dietary tryptophan in the morning in sows. J Sci Food Agric. 2018; 99(6):3005-3016. DOI: 10.1002/jsfa.9514. View

Weaver S, Laporta J, Moore S, Hernandez L . Serotonin and calcium homeostasis during the transition period. Domest Anim Endocrinol. 2016; 56 Suppl:S147-54. DOI: 10.1016/j.domaniend.2015.11.004. View

Rootwelt V, Reksen O, Farstad W, Framstad T . Associations between intrapartum death and piglet, placental, and umbilical characteristics. J Anim Sci. 2012; 90(12):4289-96. DOI: 10.2527/jas.2012-5238. View

Paulicks B, Pampuch F, Roth-Maier D . Studies on the tryptophan requirement of lactating sows. Part 1: Estimation of the tryptophan requirement by performance. J Anim Physiol Anim Nutr (Berl). 2006; 90(11-12):474-81. DOI: 10.1111/j.1439-0396.2006.00629.x. View

Zhao F, Ma C, Zhao G, Wang G, Li X, Yang K . Rumen-Protected 5-Hydroxytryptophan Improves Sheep Melatonin Synthesis in the Pineal Gland and Intestinal Tract. Med Sci Monit. 2019; 25:3605-3616. PMC: 6534969. DOI: 10.12659/MSM.915909. View

10.

Miao J, Adewole D, Liu S, Xi P, Yang C, Yin Y . Tryptophan Supplementation Increases Reproduction Performance, Milk Yield, and Milk Composition in Lactating Sows and Growth Performance of Their Piglets. J Agric Food Chem. 2019; 67(18):5096-5104. DOI: 10.1021/acs.jafc.9b00446. View

11.

Thakor A, Allison B, Niu Y, Botting K, Seron-Ferre M, Herrera E . Melatonin modulates the fetal cardiovascular defense response to acute hypoxia. J Pineal Res. 2015; 59(1):80-90. PMC: 4528231. DOI: 10.1111/jpi.12242. View

12.

Andersson H . Plasma melatonin levels in relation to the light-dark cycle and parental background in domestic pigs. Acta Vet Scand. 2001; 42(2):287-94. PMC: 2202321. DOI: 10.1186/1751-0147-42-287. View

13.

Fan Z, Yang X, Kim J, Menon D, Baidoo S . Effects of dietary tryptophan:lysine ratio on the reproductive performance of primiparous and multiparous lactating sows. Anim Reprod Sci. 2016; 170:128-34. DOI: 10.1016/j.anireprosci.2016.05.001. View

14.

Hernandez-Castellano L, Hernandez L, Weaver S, Bruckmaier R . Increased serum serotonin improves parturient calcium homeostasis in dairy cows. J Dairy Sci. 2016; 100(2):1580-1587. DOI: 10.3168/jds.2016-11638. View

15.

Brougham B, Weaver A, Swinbourne A, Lewis Baida B, Kelly J, Walker S . Maternal Supplementation with Dietary Betaine during Gestation to Improve Twin Lamb Survival. Animals (Basel). 2020; 10(10). PMC: 7601746. DOI: 10.3390/ani10101749. View

16.

Laporta J, Peters T, Weaver S, Merriman K, Hernandez L . Feeding 5-hydroxy-l-tryptophan during the transition from pregnancy to lactation increases calcium mobilization from bone in rats. Domest Anim Endocrinol. 2013; 44(4):176-84. DOI: 10.1016/j.domaniend.2013.01.005. View

17.

Mosnier E, Le Floch N, Etienne M, Ramaekers P, Seve B, Pere M . Reduced feed intake of lactating primiparous sows is associated with increased insulin resistance during the peripartum period and is not modified through supplementation with dietary tryptophan. J Anim Sci. 2009; 88(2):612-25. DOI: 10.2527/jas.2008-1768. View

18.

Yuan T, Zhu Y, Shi M, Li T, Li N, Wu G . Within-litter variation in birth weight: impact of nutritional status in the sow. J Zhejiang Univ Sci B. 2015; 16(6):417-35. PMC: 4471594. DOI: 10.1631/jzus.B1500010. View

19.

Pampuch F, Paulicks B, Roth-Maier D . Studies on the tryptophan requirement of lactating sows. Part 2: Estimation of the tryptophan requirement by physiological criteria. J Anim Physiol Anim Nutr (Berl). 2006; 90(11-12):482-6. DOI: 10.1111/j.1439-0396.2006.00630.x. View

20.

OMahony S, Clarke G, Borre Y, Dinan T, Cryan J . Serotonin, tryptophan metabolism and the brain-gut-microbiome axis. Behav Brain Res. 2014; 277:32-48. DOI: 10.1016/j.bbr.2014.07.027. View