Epigenetic Regulation of Inflammatory Responses in the Context of Physical Activity

Overview

Journal Genes (Basel)

Publisher MDPI

Date 2021 Sep 28

PMID 34573295

Citations 9

Authors

Maciej Tarnowski

Patrycja Kopytko

Katarzyna Piotrowska

Affiliations

Soon will be listed here.

Abstract

Epigenetic modifications occur in response to environmental changes and play a fundamental role in the regulation of gene expression. PA is found to elicit an inflammatory response, both from the innate and adaptive divisions of the immunological system. The inflammatory reaction is considered a vital trigger of epigenetic changes that in turn modulate inflammatory actions. The tissue responses to PA involve local and general changes. The epigenetic mechanisms involved include: DNA methylation, histone proteins modification and microRNA. All of them affect genetic expression in an inflammatory milieu in physical exercise depending on the magnitude of physiological stress experienced by the exerciser. PA may evoke acute or chronic biochemical and physiological responses and have a positive or negative immunomodulatory effect.

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