Recent Advances in Hydrogels: Ophthalmic Applications in Cell Delivery, Vitreous Substitutes, and Ocular Adhesives

Overview

Journal Biomedicines

Specialty Biomedical Engineering

Date 2021 Sep 28

PMID 34572389

Citations 10

Authors

Kenny T Lin

Athena Wang

Alexandra B Nguyen

Janaki Iyer

Simon D Tran

Affiliations

Soon will be listed here.

Abstract

With the prevalence of eye diseases, such as cataracts, retinal degenerative diseases, and glaucoma, different treatments including lens replacement, vitrectomy, and stem cell transplantation have been developed; however, they are not without their respective shortcomings. For example, current methods to seal corneal incisions induced by cataract surgery, such as suturing and stromal hydration, are less than ideal due to the potential for surgically induced astigmatism or wound leakage. Vitrectomy performed on patients with diabetic retinopathy requires an artificial vitreous substitute, with current offerings having many shortcomings such as retinal toxicity. The use of stem cells has also been investigated in retinal degenerative diseases; however, an optimal delivery system is required for successful transplantation. The incorporation of hydrogels into ocular therapy has been a critical focus in overcoming the limitations of current treatments. Previous reviews have extensively documented the use of hydrogels in drug delivery; thus, the goal of this review is to discuss recent advances in hydrogel technology in surgical applications, including dendrimer and gelatin-based hydrogels for ocular adhesives and a variety of different polymers for vitreous substitutes, as well as recent advances in hydrogel-based retinal pigment epithelium (RPE) and retinal progenitor cell (RPC) delivery to the retina.

Citing Articles

Vitrectomy for cases of diabetic retinopathy.

Shaikh N, Kumar V, Ramachandran A, Venkatesh R, Tekchandani U, Tyagi M Indian J Ophthalmol. 2024; 72(12):1704-1713.

PMID: 39186637 PMC: 11727963. DOI: 10.4103/IJO.IJO_30_24.

Biopolymeric Innovations in Ophthalmic Surgery: Enhancing Devices and Drug Delivery Systems.

Wu K, Khan S, Liao Z, Marchand M, Tran S Polymers (Basel). 2024; 16(12).

PMID: 38932068 PMC: 11207407. DOI: 10.3390/polym16121717.

Hydrogels in Ophthalmology: Novel Strategies for Overcoming Therapeutic Challenges.

Wu K, Akbar D, Giunta M, Kalevar A, Tran S Materials (Basel). 2024; 17(1).

PMID: 38203940 PMC: 10780040. DOI: 10.3390/ma17010086.

Biomaterials used for tissue engineering of barrier-forming cell monolayers in the eye.

Sasseville S, Karami S, Tchatchouang A, Charpentier P, Anney P, Gobert D Front Bioeng Biotechnol. 2023; 11:1269385.

PMID: 37840667 PMC: 10569698. DOI: 10.3389/fbioe.2023.1269385.

Retinal ganglion cell repopulation for vision restoration in optic neuropathy: a roadmap from the RReSTORe Consortium.

Soucy J, Aguzzi E, Cho J, Gilhooley M, Keuthan C, Luo Z Mol Neurodegener. 2023; 18(1):64.

PMID: 37735444 PMC: 10514988. DOI: 10.1186/s13024-023-00655-y.

References

Chenault H, Bhatia S, Dimaio W, Vincent G, Camacho W, Behrens A . Sealing and healing of clear corneal incisions with an improved dextran aldehyde-PEG amine tissue adhesive. Curr Eye Res. 2011; 36(11):997-1004. DOI: 10.3109/02713683.2011.606590. View

Sani E, Kheirkhah A, Rana D, Sun Z, Foulsham W, Sheikhi A . Sutureless repair of corneal injuries using naturally derived bioadhesive hydrogels. Sci Adv. 2019; 5(3):eaav1281. PMC: 6426459. DOI: 10.1126/sciadv.aav1281. View

Rizwan M, Yahya R, Hassan A, Yar M, Azzahari A, Selvanathan V . pH Sensitive Hydrogels in Drug Delivery: Brief History, Properties, Swelling, and Release Mechanism, Material Selection and Applications. Polymers (Basel). 2019; 9(4). PMC: 6432076. DOI: 10.3390/polym9040137. View

Wert K, Lin J, Tsang S . General pathophysiology in retinal degeneration. Dev Ophthalmol. 2014; 53:33-43. PMC: 4405532. DOI: 10.1159/000357294. View

Tang Z, Jiang F, Zhang Y, Zhang Y, YuanYang , Huang X . Mussel-inspired injectable hydrogel and its counterpart for actuating proliferation and neuronal differentiation of retinal progenitor cells. Biomaterials. 2018; 194:57-72. DOI: 10.1016/j.biomaterials.2018.12.015. View

Davis G . The Evolution of Cataract Surgery. Mo Med. 2016; 113(1):58-62. PMC: 6139750. View

Tram N, Jiang P, Torres-Flores T, Jacobs K, Chandler H, Swindle-Reilly K . A Hydrogel Vitreous Substitute that Releases Antioxidant. Macromol Biosci. 2019; 20(2):e1900305. DOI: 10.1002/mabi.201900305. View

Patel A, Cholkar K, Agrahari V, Mitra A . Ocular drug delivery systems: An overview. World J Pharmacol. 2015; 2(2):47-64. PMC: 4289909. DOI: 10.5497/wjp.v2.i2.47. View

Calladine D, Ward M, Packard R . Adherent ocular bandage for clear corneal incisions used in cataract surgery. J Cataract Refract Surg. 2010; 36(11):1839-48. DOI: 10.1016/j.jcrs.2010.06.058. View

10.

Cox J, Eliott D, Sobrin L . Inflammatory Complications of Intravitreal Anti-VEGF Injections. J Clin Med. 2021; 10(5). PMC: 7957879. DOI: 10.3390/jcm10050981. View

11.

Kanclerz P, Grzybowski A . Complications Associated with the Use of Expandable Gases in Vitrectomy. J Ophthalmol. 2018; 2018:8606494. PMC: 6276446. DOI: 10.1155/2018/8606494. View

12.

Satitpitakul V, Uramphorn N, Kasetsuwan N . Factors predicting change in corneal astigmatism following suture removal in post-penetrating keratoplasty patients. Clin Ophthalmol. 2019; 13:1593-1597. PMC: 6709029. DOI: 10.2147/OPTH.S213470. View

13.

Discher D, Smith L, Cho S, Colasurdo M, Garcia A, Safran S . Matrix Mechanosensing: From Scaling Concepts in 'Omics Data to Mechanisms in the Nucleus, Regeneration, and Cancer. Annu Rev Biophys. 2017; 46:295-315. PMC: 5444306. DOI: 10.1146/annurev-biophys-062215-011206. View

14.

Cai X, Conley S, Naash M . RPE65: role in the visual cycle, human retinal disease, and gene therapy. Ophthalmic Genet. 2009; 30(2):57-62. PMC: 2821785. DOI: 10.1080/13816810802626399. View

15.

Duh E, Sun J, Stitt A . Diabetic retinopathy: current understanding, mechanisms, and treatment strategies. JCI Insight. 2017; 2(14). PMC: 5518557. DOI: 10.1172/jci.insight.93751. View

16.

Rim M, Choi J, Park A, Youn J, Lee S, Kim N . Characterization of Gelatin/Gellan Gum/Glycol Chitosan Ternary Hydrogel for Retinal Pigment Epithelial Tissue Reconstruction Materials. ACS Appl Bio Mater. 2022; 3(9):6079-6087. DOI: 10.1021/acsabm.0c00672. View

17.

Kador K, Goldberg J . Scaffolds and stem cells: delivery of cell transplants for retinal degenerations. Expert Rev Ophthalmol. 2013; 7(5):459-470. PMC: 3622368. DOI: 10.1586/eop.12.56. View

18.

Behar-Cohen F, Baillet G, de Ayguavives T, Garcia P, Krutmann J, Pena-Garcia P . Ultraviolet damage to the eye revisited: eye-sun protection factor (E-SPF®), a new ultraviolet protection label for eyewear. Clin Ophthalmol. 2014; 8:87-104. PMC: 3872277. DOI: 10.2147/OPTH.S46189. View

19.

Henry C, Flynn Jr H, Miller D, Schefler A, Forster R, Alfonso E . Delayed-onset endophthalmitis associated with corneal suture infections. J Ophthalmic Inflamm Infect. 2013; 3(1):51. PMC: 3717107. DOI: 10.1186/1869-5760-3-51. View

20.

. Trends in prevalence of blindness and distance and near vision impairment over 30 years: an analysis for the Global Burden of Disease Study. Lancet Glob Health. 2020; 9(2):e130-e143. PMC: 7820390. DOI: 10.1016/S2214-109X(20)30425-3. View