Intermittent Sequential Pneumatic Compression Improves Coupling Between Cerebral Oxyhaemoglobin and Arterial Blood Pressure in Patients with Cerebral Infarction

Overview

Journal Biology (Basel)

Publisher MDPI

Specialty Biology

Date 2021 Sep 28

PMID 34571746

Authors

Wenhao Li

Gongcheng Xu

Congcong Huo

Hui Xie

Zeping Lv

Haihong Zhao

Zengyong Li

Affiliations

Soon will be listed here.

Abstract

This study aims to explore the effect of intermittent sequential pneumatic compression (ISPC) intervention on the coupling relationship between arterial blood pressure (ABP) and changes in oxyhaemoglobin (Δ [OHb]). The coupling strength between the two physiological systems was estimated using a coupling function based on dynamic Bayesian inference. The participants were 22 cerebral infarction patients and 20 age- and sex-matched healthy controls. Compared with resting state, the coupling strength from ABP to Δ [OHb] oscillations was significantly lower in the bilateral prefrontal cortex (PFC), sensorimotor cortex (SMC), and temporal lobe cortex (TLC) during the ISPC intervention in cerebral infarction patients in interval II. Additionally, the coupling strength was significantly lower in the bilateral SMC in both groups in interval III. These findings indicate that ISPC intervention may facilitate cerebral circulation in the bilateral PFC, SMC, and TLC in cerebral infarction patients. ISPC may promote motor function recovery through its positive influences on motor-related networks. Furthermore, the coupling between Δ [OHb] and ABP allows non-invasive assessments of autoregulatory function to quantitatively assess the effect of rehabilitation tasks and to guide therapy in clinical situations.

References

Sheldon R, Roseguini B, Laughlin M, Newcomer S . New insights into the physiologic basis for intermittent pneumatic limb compression as a therapeutic strategy for peripheral artery disease. J Vasc Surg. 2013; 58(6):1688-96. DOI: 10.1016/j.jvs.2013.08.094. View

Sheldon R, Roseguini B, Thyfault J, Crist B, Laughlin M, Newcomer S . Acute impact of intermittent pneumatic leg compression frequency on limb hemodynamics, vascular function, and skeletal muscle gene expression in humans. J Appl Physiol (1985). 2012; 112(12):2099-109. PMC: 3378395. DOI: 10.1152/japplphysiol.00042.2012. View

Li W, Zhang M, Huo C, Xu G, Chen W, Wang D . Time-evolving coupling functions for evaluating the interaction between cerebral oxyhemoglobin and arterial blood pressure with hypertension. Med Phys. 2020; 48(4):2027-2037. DOI: 10.1002/mp.14627. View

Michaels A, Accad M, Ports T, Grossman W . Left ventricular systolic unloading and augmentation of intracoronary pressure and Doppler flow during enhanced external counterpulsation. Circulation. 2002; 106(10):1237-42. DOI: 10.1161/01.cir.0000028336.95629.b0. View

Zhang H, Zhang Y, Lu C, Ma S, Zang Y, Zhu C . Functional connectivity as revealed by independent component analysis of resting-state fNIRS measurements. Neuroimage. 2010; 51(3):1150-61. DOI: 10.1016/j.neuroimage.2010.02.080. View

Elting J, Tas J, Aries M, Czosnyka M, Maurits N . Dynamic cerebral autoregulation estimates derived from near infrared spectroscopy and transcranial Doppler are similar after correction for transit time and blood flow and blood volume oscillations. J Cereb Blood Flow Metab. 2018; 40(1):135-149. PMC: 6927073. DOI: 10.1177/0271678X18806107. View

Scholkmann F, Kleiser S, Metz A, Zimmermann R, Pavia J, Wolf U . A review on continuous wave functional near-infrared spectroscopy and imaging instrumentation and methodology. Neuroimage. 2013; 85 Pt 1:6-27. DOI: 10.1016/j.neuroimage.2013.05.004. View

Su H, Huo C, Wang B, Li W, Xu G, Liu Q . Alterations in the coupling functions between cerebral oxyhaemoglobin and arterial blood pressure signals in post-stroke subjects. PLoS One. 2018; 13(4):e0195936. PMC: 5905974. DOI: 10.1371/journal.pone.0195936. View

Hamner J, Tan C . Relative contributions of sympathetic, cholinergic, and myogenic mechanisms to cerebral autoregulation. Stroke. 2014; 45(6):1771-7. PMC: 4102642. DOI: 10.1161/STROKEAHA.114.005293. View

10.

Tian F, Tarumi T, Liu H, Zhang R, Chalak L . Wavelet coherence analysis of dynamic cerebral autoregulation in neonatal hypoxic-ischemic encephalopathy. Neuroimage Clin. 2016; 11:124-132. PMC: 4753811. DOI: 10.1016/j.nicl.2016.01.020. View

11.

Billinger S, Coughenour E, MacKay-Lyons M, Ivey F . Reduced cardiorespiratory fitness after stroke: biological consequences and exercise-induced adaptations. Stroke Res Treat. 2011; 2012:959120. PMC: 3159380. DOI: 10.1155/2012/959120. View

12.

Lin W, Xiong L, Han J, Leung H, Leung T, Soo Y . Increasing pressure of external counterpulsation augments blood pressure but not cerebral blood flow velocity in ischemic stroke. J Clin Neurosci. 2014; 21(7):1148-52. DOI: 10.1016/j.jocn.2013.09.023. View

13.

Scholkmann F, Spichtig S, Muehlemann T, Wolf M . How to detect and reduce movement artifacts in near-infrared imaging using moving standard deviation and spline interpolation. Physiol Meas. 2010; 31(5):649-62. DOI: 10.1088/0967-3334/31/5/004. View

14.

Liu J, Xiong L, Stinear C, Leung H, Leung T, Wong K . External counterpulsation enhances neuroplasticity to promote stroke recovery. J Neurol Neurosurg Psychiatry. 2018; 90(3):361-363. DOI: 10.1136/jnnp-2018-318185. View

15.

Stankovski T, Ticcinelli V, McClintock P, Stefanovska A . Neural Cross-Frequency Coupling Functions. Front Syst Neurosci. 2017; 11:33. PMC: 5471314. DOI: 10.3389/fnsys.2017.00033. View

16.

Chen L, Liu K, Qi W, Joneschild E, Tan X, Seaber A . Role of nitric oxide in vasodilation in upstream muscle during intermittent pneumatic compression. J Appl Physiol (1985). 2002; 92(2):559-66. DOI: 10.1152/japplphysiol.00365.2001. View

17.

Sasai S, Homae F, Watanabe H, Sasaki A, Tanabe H, Sadato N . A NIRS-fMRI study of resting state network. Neuroimage. 2012; 63(1):179-93. DOI: 10.1016/j.neuroimage.2012.06.011. View

18.

Teixeira-Salmela L, Parreira V, Britto R, Brant T, Inacio E, Alcantara T . Respiratory pressures and thoracoabdominal motion in community-dwelling chronic stroke survivors. Arch Phys Med Rehabil. 2005; 86(10):1974-8. DOI: 10.1016/j.apmr.2005.03.035. View

19.

Li Z, Zhang M, Xin Q, Luo S, Cui R, Zhou W . Age-related changes in spontaneous oscillations assessed by wavelet transform of cerebral oxygenation and arterial blood pressure signals. J Cereb Blood Flow Metab. 2013; 33(5):692-9. PMC: 3652694. DOI: 10.1038/jcbfm.2013.4. View

20.

Vasta R, Cutini S, Cerasa A, Gramigna V, Olivadese G, Arabia G . Physiological Aging Influence on Brain Hemodynamic Activity during Task-Switching: A fNIRS Study. Front Aging Neurosci. 2018; 9:433. PMC: 5767724. DOI: 10.3389/fnagi.2017.00433. View