A 3D-printed Modular Magnetic Digital Microfluidic Architecture for On-demand Bioanalysis

Overview

Journal Microsyst Nanoeng

Date 2021 Sep 27

PMID 34567660

Citations 18

Authors

Pojchanun Kanitthamniyom

Aiwu Zhou

Shilun Feng

Aiqun Liu

Shawn Vasoo

Yi Zhang

Affiliations

Soon will be listed here.

Abstract

Magnetic digital microfluidics (MDM) manipulates fluids in the form of droplets on an open substrate, and incorporates surface energy traps (SETs) to facilitate the droplet manipulation. Conventional MDM devices are fabricated monolithically, which makes it difficult to modify the device configuration without completely overhauling the original design. In this paper, we present a modular MDM architecture that enables rapid on-demand configuration and re-configuration of MDM platforms for customized bioanalyses. Each modular component contains a SET and a Lego-like antistud that fits onto a base board with Lego-like studs. We illustrate the versatility of the modular MDM architecture in biomarker sensing, pathogen identification, antibiotic resistance determination, and biochemical quantification by demonstrating immunoassays, phenotypical assays and enzymatic assays on various modular MDM platforms configured on demand to accomplish the fluidic operations required by assorted bioanalytical assays. The modular MDM architecture promises great potential for point-of-care diagnostics by offering on-demand customization of testing platforms for various categories of diagnostic assays. It also provides a new avenue for microfluidic assay development with its high configurability which would significantly reduce the time and cost of the development cycle.

Citing Articles

Emerging Trends in Integrated Digital Microfluidic Platforms for Next-Generation Immunoassays.

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A Miniature Modular Fluorescence Flow Cytometry System.

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A Lego-Like Reconfigurable Microfluidic Stabilizer System with Tunable Fluidic RC Constants and Stabilization Ratios.

Zhuge W, Li W, Wang K, Chen Z, Wu C, Jiang K Micromachines (Basel). 2024; 15(7).

PMID: 39064354 PMC: 11278724. DOI: 10.3390/mi15070843.

Internal flow in sessile droplets induced by substrate oscillation: towards enhanced mixing and mass transfer in microfluidic systems.

Zhang T, Zhou P, Simon T, Cui T Microsyst Nanoeng. 2024; 10:86.

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