Filamentous Bacteriophage-A Powerful Carrier for Glioma Therapy

Overview

Journal Front Immunol

Specialty Allergy & Immunology

Date 2021 Sep 27

PMID 34566987

Citations 8

Authors

Yicun Wang

Jiyao Sheng

Jin Chai

Cuilin Zhu

Xin Li

Wei Yang

Ranji Cui

Tongtong Ge

Affiliations

Soon will be listed here.

Abstract

Glioma is a life-threatening malignant tumor. Resistance to traditional treatments and tumor recurrence present major challenges in treating and managing this disease, consequently, new therapeutic strategies must be developed. Crossing the blood-brain barrier (BBB) is another challenge for most drug vectors and therapy medications. Filamentous bacteriophage can enter the brain across the BBB. Compared to traditional drug vectors, phage-based drugs offer thermodynamic stability, biocompatibility, homogeneity, high carrying capacity, self-assembly, scalability, and low toxicity. Tumor-targeting peptides from phage library and phages displaying targeting peptides are ideal drug delivery agents. This review summarized recent studies on phage-based glioma therapy and shed light on the developing therapeutics phage in the personalized treatment of glioma.

Citing Articles

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References

Carrera M, Kaufmann G, Mee J, Meijler M, Koob G, Janda K . Treating cocaine addiction with viruses. Proc Natl Acad Sci U S A. 2004; 101(28):10416-21. PMC: 478586. DOI: 10.1073/pnas.0403795101. View

Kohno T, Tam L, Stevens S, Louie J . Binding characteristics of tumor necrosis factor receptor-Fc fusion proteins vs anti-tumor necrosis factor mAbs. J Investig Dermatol Symp Proc. 2007; 12(1):5-8. DOI: 10.1038/sj.jidsymp.5650034. View

Kim Y, Lillo A, Steiniger S, Liu Y, Ballatore C, Anichini A . Targeting heat shock proteins on cancer cells: selection, characterization, and cell-penetrating properties of a peptidic GRP78 ligand. Biochemistry. 2006; 45(31):9434-44. DOI: 10.1021/bi060264j. View

Rorive S, Belot N, Decaestecker C, Lefranc F, Gordower L, Micik S . Galectin-1 is highly expressed in human gliomas with relevance for modulation of invasion of tumor astrocytes into the brain parenchyma. Glia. 2001; 33(3):241-55. DOI: 10.1002/1098-1136(200103)33:3<241::aid-glia1023>3.0.co;2-1. View

Barth S, Weidenmuller U, Tur M, Schmidt M, Engert A . Combining phage display and screening of cDNA expression libraries: a new approach for identifying the target antigen of an scFv preselected by phage display. J Mol Biol. 2000; 301(4):751-7. DOI: 10.1006/jmbi.2000.4038. View

Nduom E, Yang C, Merrill M, Zhuang Z, Lonser R . Characterization of the blood-brain barrier of metastatic and primary malignant neoplasms. J Neurosurg. 2013; 119(2):427-33. PMC: 4746720. DOI: 10.3171/2013.3.JNS122226. View

Chen C, Duan Z, Yuan Y, Li R, Pang L, Liang J . Peptide-22 and Cyclic RGD Functionalized Liposomes for Glioma Targeting Drug Delivery Overcoming BBB and BBTB. ACS Appl Mater Interfaces. 2017; 9(7):5864-5873. DOI: 10.1021/acsami.6b15831. View

Maszewska A . [Phage associated polysaccharide depolymerases - characteristics and application]. Postepy Hig Med Dosw (Online). 2015; 69:690-702. DOI: 10.5604/17322693.1157422. View

Peng C, Chen Z, Wang S, Wang H, Qiu W, Zhao L . The Error-Prone DNA Polymerase κ Promotes Temozolomide Resistance in Glioblastoma through Rad17-Dependent Activation of ATR-Chk1 Signaling. Cancer Res. 2016; 76(8):2340-53. DOI: 10.1158/0008-5472.CAN-15-1884. View

10.

Luo W, Ko E, Hsu J, Wang X, Ferrone S . Targeting melanoma cells with human high molecular weight-melanoma associated antigen-specific antibodies elicited by a peptide mimotope: functional effects. J Immunol. 2006; 176(10):6046-54. DOI: 10.4049/jimmunol.176.10.6046. View

11.

Detti B, Scoccianti S, Teriaca M, Maragna V, Lorenzetti V, Lucidi S . Bevacizumab in recurrent high-grade glioma: a single institution retrospective analysis on 92 patients. Radiol Med. 2021; 126(9):1249-1254. PMC: 8370943. DOI: 10.1007/s11547-021-01381-5. View

12.

Hua Y, Luo T, Yang Y, Dong D, Wang R, Wang Y . Phage Therapy as a Promising New Treatment for Lung Infection Caused by Carbapenem-Resistant in Mice. Front Microbiol. 2018; 8:2659. PMC: 5767256. DOI: 10.3389/fmicb.2017.02659. View

13.

Motomura K, Chalise L, Ohka F, Aoki K, Tanahashi K, Hirano M . Impact of the extent of resection on the survival of patients with grade II and III gliomas using awake brain mapping. J Neurooncol. 2021; 153(2):361-372. DOI: 10.1007/s11060-021-03776-w. View

14.

Chongchai A, Waramit S, Suwan K, Al-Bahrani M, Udomruk S, Phitak T . Bacteriophage-mediated therapy of chondrosarcoma by selective delivery of the tumor necrosis factor alpha (TNFα) gene. FASEB J. 2021; 35(5):e21487. DOI: 10.1096/fj.202002539R. View

15.

Rahn J, Lun X, Jorch S, Hao X, Venugopal C, Vora P . Development of a peptide-based delivery platform for targeting malignant brain tumors. Biomaterials. 2020; 252:120105. DOI: 10.1016/j.biomaterials.2020.120105. View

16.

van Lith S, Roodink I, Verhoeff J, Makinen P, Lappalainen J, Yla-Herttuala S . In vivo phage display screening for tumor vascular targets in glioblastoma identifies a llama nanobody against dynactin-1-p150Glued. Oncotarget. 2016; 7(44):71594-71607. PMC: 5342104. DOI: 10.18632/oncotarget.12261. View

17.

Zhou C, Kang J, Wang X, Wei W, Jiang W . Phage display screening identifies a novel peptide to suppress ovarian cancer cells in vitro and in vivo in mouse models. BMC Cancer. 2015; 15:889. PMC: 4641363. DOI: 10.1186/s12885-015-1891-8. View

18.

Ksendzovsky A, Walbridge S, Saunders R, Asthagiri A, Heiss J, Lonser R . Convection-enhanced delivery of M13 bacteriophage to the brain. J Neurosurg. 2012; 117(2):197-203. PMC: 3786326. DOI: 10.3171/2012.4.JNS111528. View

19.

Margot S, Saulnier A, Barban V . [Phages and vaccination: towards new opportunities?]. Virologie (Montrouge). 2020; 24(1):37-47. DOI: 10.1684/vir.2019.0794. View

20.

Fahey O, Koth S, Bergsbaken J, Jones H, Trapskin P . Automated parenteral chemotherapy dose-banding to improve patient safety and decrease drug costs. J Oncol Pharm Pract. 2019; 26(2):345-350. DOI: 10.1177/1078155219846958. View