Long Noncoding RNA and Atrial Fibrillation

Overview

Journal Zhong Nan Da Xue Xue Bao Yi Xue Ban

Specialty General Medicine

Date 2021 Sep 27

PMID 34565733

Citations 1

Authors

Boyao Yu

Chunfan Xie

Siyang Yu

Yongbin Hu

Affiliations

Soon will be listed here.

Abstract

Atrial fibrillation (AF), a common arrhythmia that usually occurs in patients with heart disease, is one of the leading causes for mortality and disability worldwide. Current drug therapy for AF patients lacks sufficient efficacy and has side effects. Radiofrequency ablation is more effective than traditional drug therapy, but this invasive procedure is associated with potential risks and postoperative recurrence, limiting the clinical benefits for AF patients. Therefore, it is necessary to expand our understanding about the underlying molecular mechanism of AF and to explore the new therapeutic strategies. Long noncoding RNA (lncRNA) is a set of noncoding RNA longer than 200 nucleotides. Growing evidence indicates that lncRNA is involved in numerous pathophysiological processes of AF, such as structural remodeling, electrical remodeling, renin-angiotensin system, abnormal calcium regulation, etc. In addition, lncRNA involved in structural remodeling and electrical remodeling has the potential to be a novel target for the diagnosis and treatment of AF, and lncRNA involved in autonomic nerve remodeling may bring new enlightenment for the prognosis and recurrence of AF.

Citing Articles

Nano drugs delivery system: A novel promise for the treatment of atrial fibrillation.

Wang Z, Tong Q, Li T, Qian Y Front Cardiovasc Med. 2022; 9:906350.

PMID: 36386310 PMC: 9645120. DOI: 10.3389/fcvm.2022.906350.

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