Kynurenine Derivative 3-HAA is an Agonist Ligand for Transcription Factor YY1

Overview

Journal J Hematol Oncol

Publisher Biomed Central

Specialties Hematology
Oncology

Date 2021 Sep 26

PMID 34563230

Citations 4

Authors

Zhaopeng Shi

Guifang Gan

Xiang Xu

Jieying Zhang

Yuan Yuan

Bo Bi

Xianfu Gao

Pengfei Xu

Wenbin Zeng

Jixi Li

Youqiong Ye

Aiwu Zhou

Naixia Zhang

Wen Liu

Shuhai Lin

Jun Mi

Affiliations

Soon will be listed here.

Abstract

The 3-hydroxyanthranilic acid (3-HAA), a derivative of kynurenine, was reported to suppress tumor growth. However, the function of 3-HAA largely remains unclear. Here, we report that 3-hydroxyanthranilic acid (3-HAA) is lower in tumor cells, while adding exogenous 3-HAA induces apoptosis in hepatocellular carcinoma by binding YY1. This 3-HAA binding of YY1 leads to phosphorylation of YY1 at the Thr 398 by PKCζ, concomitantly enhances YY1 chromatin binding activity to increase expression of target genes. These findings demonstrate that 3-HAA is a ligand of YY1, suggesting it is a promising therapeutic candidate for HCC.

Citing Articles

3-Hydroxyanthranic acid inhibits growth of oral squamous carcinoma cells through growth arrest and DNA damage inducible alpha.

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Tryptophan metabolism in digestive system tumors: unraveling the pathways and implications.

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Puerarin alleviates inflammation and pathological damage in colitis mice by regulating metabolism and gut microbiota.

Zou Y, Ding W, Wu Y, Chen T, Ruan Z Front Microbiol. 2023; 14:1279029.

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Kynurenine catabolic enzyme KMO regulates HCC growth.

Shi Z, Gan G, Gao X, Chen F, Mi J Clin Transl Med. 2022; 12(2):e697.

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