Cell Activity Modulation and Its Specific Function Maintenance by Bioinspired Electromechanical Nanogenerator

Overview

Journal Sci Adv

Specialties Biology
Science

Date 2021 Sep 24

PMID 34559554

Citations 8

Authors

Tong Li

Chuanmei Shi

Fei Jin

Fan Yang

Long Gu

Ting Wang

Wei Dong

Zhang-Qi Feng

Affiliations

Soon will be listed here.

Abstract

The biophysical characteristics of the extracellular matrix (ECM), such as a three-dimensional (3D) network and bioelectricity, have a profound influence on cell development, migration, function expression, etc. Here, inspired by these biophysical cues of ECM, we develop an electromechanical coupling bio-nanogenerator (bio-NG) composed of highly discrete piezoelectric fibers. It can generate surface piezopotential up to millivolts by cell inherent force and thus provide in situ electrical stimulation for the living cells. Besides, the unique 3D space in the bio-NGs provides an ECM-like growth microenvironment for cells. As a result, our bio-NGs effectively promote cell viability and development and, more importantly, maintain its specific functional expression. These advanced in vitro bio-NGs are expected to fill the gap between the inaccurate 2D systems and the expensive and time-consuming animal models, mimicking the complexity of the ECM and the physiological relevance of an in vivo biological system.

Citing Articles

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