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Recent Progress on Tourette Syndrome

Overview
Journal Fac Rev
Date 2021 Sep 24
PMID 34557874
Citations 3
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Abstract

Tic disorders and Tourette syndrome are the most common movement disorders in children and are characterized by movements or vocalizations. Clinically, Tourette syndrome is frequently associated with comorbid psychiatric symptoms. Although dysfunction of cortical-striatal-thalamic-cortical circuits with aberrant neurotransmitter function has been considered the proximate cause of tics, the mechanism underlying this association is unclear. Recently, many studies have been conducted to elucidate the epidemiology, clinical course, comorbid symptoms, and pathophysiology of tic disorders by using laboratory studies, neuroimaging, electrophysiological testing, environmental exposure, and genetic testing. In addition, many researchers have focused on treatment for tics, including behavioral therapy, pharmacological treatment, and surgical treatment. Here, we provide an overview of recent progress on Tourette syndrome.

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References
1.
Groth C, Skov L, Lange T, Debes N . Predictors of the Clinical Course of Tourette Syndrome: A Longitudinal Study. J Child Neurol. 2019; 34(14):913-921. DOI: 10.1177/0883073819867245. View

2.
Mataix-Cols D, Isomura K, Perez-Vigil A, Chang Z, Ruck C, Larsson K . Familial Risks of Tourette Syndrome and Chronic Tic Disorders. A Population-Based Cohort Study. JAMA Psychiatry. 2015; 72(8):787-93. DOI: 10.1001/jamapsychiatry.2015.0627. View

3.
Welch J, Lu J, Rodriguiz R, Trotta N, Peca J, Ding J . Cortico-striatal synaptic defects and OCD-like behaviours in Sapap3-mutant mice. Nature. 2007; 448(7156):894-900. PMC: 2442572. DOI: 10.1038/nature06104. View

4.
Miller L, Scharf J, Mathews C, Ben-Shlomo Y . Tourette syndrome and chronic tic disorder are associated with lower socio-economic status: findings from the Avon Longitudinal Study of Parents and Children cohort. Dev Med Child Neurol. 2013; 56(2):157-63. PMC: 3908357. DOI: 10.1111/dmcn.12318. View

5.
Openneer T, Forde N, Akkermans S, Naaijen J, Buitelaar J, Hoekstra P . Executive function in children with Tourette syndrome and attention-deficit/hyperactivity disorder: Cross-disorder or unique impairments?. Cortex. 2020; 124:176-187. DOI: 10.1016/j.cortex.2019.11.007. View