Cohort Studies of Long-term Exposure to Outdoor Particulate Matter and Risks of Cancer: A Systematic Review and Meta-analysis

Overview

Journal Innovation (Camb)

Publisher Cell Press

Specialty Biomedical Engineering

Date 2021 Sep 24

PMID 34557780

Citations 16

Authors

Pei Yu

Suying Guo

Rongbin Xu

Tingting Ye

Shanshan Li

Malcolm R Sim

Michael J Abramson

Yuming Guo

Affiliations

Soon will be listed here.

Abstract

Robust evidence is needed for the hazardous effects of outdoor particulate matter (PM) on mortality and morbidity from all types of cancers. To summarize and meta-analyze the association between PM and cancer, published articles reporting associations between outdoor PM exposure and any type of cancer with individual outcome assessment that provided a risk estimate in cohort studies were identified via systematic searches. Of 3,256 records, 47 studies covering 13 cancer sites (30 for lung cancer, 12 for breast cancer, 11 for other cancers) were included in the quantitative evaluation. The pooled relative risks (RRs) for lung cancer incidence or mortality associated with every 10-μg/m PM or PM were 1.16 (95% confidence interval [CI], 1.10-1.23; I = 81%) or 1.22 (95% CI, 1.02-1.45; I = 96%), respectively. Increased but non-significant risks were found for breast cancer. Other cancers were shown to be associated with PM exposure in some studies but not consistently and thus warrant further investigation.

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References

Cui P, Huang Y, Han J, Song F, Chen K . Ambient particulate matter and lung cancer incidence and mortality: a meta-analysis of prospective studies. Eur J Public Health. 2014; 25(2):324-9. DOI: 10.1093/eurpub/cku145. View

Sutton P, Kavanaugh-Lynch M, Plumb M, Yen I, Sarantis H, Thomsen C . California Breast Cancer Prevention Initiatives: Setting a research agenda for prevention. Reprod Toxicol. 2014; 54:11-8. DOI: 10.1016/j.reprotox.2014.09.008. View

Coleman N, Burnett R, Ezzati M, Marshall J, Robinson A, Pope 3rd C . Fine Particulate Matter Exposure and Cancer Incidence: Analysis of SEER Cancer Registry Data from 1992-2016. Environ Health Perspect. 2020; 128(10):107004. PMC: 7546438. DOI: 10.1289/EHP7246. View

Hiatt R, Haslam S, Osuch J . The breast cancer and the environment research centers: transdisciplinary research on the role of the environment in breast cancer etiology. Environ Health Perspect. 2010; 117(12):1814-22. PMC: 2799453. DOI: 10.1289/ehp.0800120. View

Heinrich J, Thiering E, Rzehak P, Kramer U, Hochadel M, Rauchfuss K . Long-term exposure to NO2 and PM10 and all-cause and cause-specific mortality in a prospective cohort of women. Occup Environ Med. 2012; 70(3):179-86. PMC: 3585480. DOI: 10.1136/oemed-2012-100876. View

Zhang Z, Yan W, Chen Q, Zhou N, Xu Y . The relationship between exposure to particulate matter and breast cancer incidence and mortality: A meta-analysis. Medicine (Baltimore). 2019; 98(50):e18349. PMC: 6922579. DOI: 10.1097/MD.0000000000018349. View

Turner M, Krewski D, Pope 3rd C, Chen Y, Gapstur S, Thun M . Long-term ambient fine particulate matter air pollution and lung cancer in a large cohort of never-smokers. Am J Respir Crit Care Med. 2011; 184(12):1374-81. DOI: 10.1164/rccm.201106-1011OC. View

DerSimonian R, Laird N . Meta-analysis in clinical trials. Control Clin Trials. 1986; 7(3):177-88. DOI: 10.1016/0197-2456(86)90046-2. View

Hales S, Blakely T, Woodward A . Air pollution and mortality in New Zealand: cohort study. J Epidemiol Community Health. 2010; 66(5):468-73. PMC: 3318234. DOI: 10.1136/jech.2010.112490. View

10.

Hart J, Bertrand K, DuPre N, James P, Vieira V, Tamimi R . Long-term Particulate Matter Exposures during Adulthood and Risk of Breast Cancer Incidence in the Nurses' Health Study II Prospective Cohort. Cancer Epidemiol Biomarkers Prev. 2016; 25(8):1274-6. PMC: 4970922. DOI: 10.1158/1055-9965.EPI-16-0246. View

11.

Pedersen M, Andersen Z, Stafoggia M, Weinmayr G, Galassi C, Sorensen M . Ambient air pollution and primary liver cancer incidence in four European cohorts within the ESCAPE project. Environ Res. 2017; 154:226-233. DOI: 10.1016/j.envres.2017.01.006. View

12.

Chen G, Wan X, Yang G, Zou X . Traffic-related air pollution and lung cancer: A meta-analysis. Thorac Cancer. 2015; 6(3):307-18. PMC: 4448375. DOI: 10.1111/1759-7714.12185. View

13.

Cheng I, Tseng C, Wu J, Yang J, Conroy S, Shariff-Marco S . Association between ambient air pollution and breast cancer risk: The multiethnic cohort study. Int J Cancer. 2019; 146(3):699-711. PMC: 6765455. DOI: 10.1002/ijc.32308. View

14.

White A, Keller J, Zhao S, Carroll R, Kaufman J, Sandler D . Air Pollution, Clustering of Particulate Matter Components, and Breast Cancer in the Sister Study: A U.S.-Wide Cohort. Environ Health Perspect. 2019; 127(10):107002. PMC: 6867190. DOI: 10.1289/EHP5131. View

15.

Shmuel S, White A, Sandler D . Residential exposure to vehicular traffic-related air pollution during childhood and breast cancer risk. Environ Res. 2017; 159:257-263. PMC: 5718152. DOI: 10.1016/j.envres.2017.08.015. View

16.

Hart J, Garshick E, Dockery D, Smith T, Ryan L, Laden F . Long-term ambient multipollutant exposures and mortality. Am J Respir Crit Care Med. 2010; 183(1):73-8. PMC: 3040395. DOI: 10.1164/rccm.200912-1903OC. View

17.

Yu W, Guo Y, Shi L, Li S . The association between long-term exposure to low-level PM2.5 and mortality in the state of Queensland, Australia: A modelling study with the difference-in-differences approach. PLoS Med. 2020; 17(6):e1003141. PMC: 7302440. DOI: 10.1371/journal.pmed.1003141. View

18.

Jorgensen J, Johansen M, Ravnskjaer L, Andersen K, Brauner E, Loft S . Long-term exposure to ambient air pollution and incidence of brain tumours: The Danish Nurse Cohort. Neurotoxicology. 2016; 55:122-130. DOI: 10.1016/j.neuro.2016.06.003. View

19.

Liu C, Tsai S, Chiu H, Wu T, Chen C, Yang C . Ambient exposure to criteria air pollutants and risk of death from bladder cancer in Taiwan. Inhal Toxicol. 2008; 21(1):48-54. DOI: 10.1080/08958370802207326. View

20.

Berkey C, Frazier A, Gardner J, Colditz G . Adolescence and breast carcinoma risk. Cancer. 1999; 85(11):2400-9. DOI: 10.1002/(sici)1097-0142(19990601)85:11<2400::aid-cncr15>3.0.co;2-o. View