Pathogenesis of Autoimmune Hepatitis

Overview

Journal World J Hepatol

Publisher Baishideng Publishing Group

Specialty Gastroenterology

Date 2021 Sep 23

PMID 34552694

Citations 6

Authors

Jun-Hua Fan

Geng-Feng Liu

Xiao-Dan Lv

Rui-Zhi Zeng

Ling-Ling Zhan

Xiao-Ping Lv

Affiliations

Soon will be listed here.

Abstract

Autoimmune hepatitis (AIH) is a chronic progressive liver disease whose etiology and pathogenesis are not yet clear. It is currently believed that the occurrence of AIH is closely related to genetic susceptibility and immune abnormalities, and other factors such as environment, viral infection and drugs that may cause immune dysfunction. This article reviews the pathogenesis of AIH and describes the latest research results in the past 5 years.

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The Usefulness of Extended Inflammation Parameters and Systemic Inflammatory Response Markers in the Diagnostics of Autoimmune Hepatitis.

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Indicator of Inflammation and NETosis-Low-Density Granulocytes as a Biomarker of Autoimmune Hepatitis.

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References

Qian J, Meng Z, Guan J, Zhang Z, Wang Y . Expression and roles of TIPE2 in autoimmune hepatitis. Exp Ther Med. 2017; 13(3):942-946. PMC: 5403299. DOI: 10.3892/etm.2017.4050. View

Higuchi T, Oka S, Furukawa H, Nakamura M, Komori A, Abiru S . Role of deleterious single nucleotide variants in the coding regions of TNFAIP3 for Japanese autoimmune hepatitis with cirrhosis. Sci Rep. 2019; 9(1):7925. PMC: 6538649. DOI: 10.1038/s41598-019-44524-5. View

Vollmer O, Felten R, Mertz P, Lebrun-Vignes B, Salem J, Arnaud L . Characterization of auto-immune hepatitis associated with the use of anti-TNFα agents: An analysis of 389 cases in VigiBase. Autoimmun Rev. 2020; 19(3):102460. DOI: 10.1016/j.autrev.2020.102460. View

Higuchi T, Oka S, Furukawa H, Tohma S, Yatsuhashi H, Migita K . Genetic risk factors for autoimmune hepatitis: implications for phenotypic heterogeneity and biomarkers for drug response. Hum Genomics. 2021; 15(1):6. PMC: 7841991. DOI: 10.1186/s40246-020-00301-4. View

Liang M, Liwen Z, Yun Z, Yanbo D, Jianping C . Serum Levels of IL-33 and Correlation with IL-4, IL-17A, and Hypergammaglobulinemia in Patients with Autoimmune Hepatitis. Mediators Inflamm. 2018; 2018:7964654. PMC: 6035854. DOI: 10.1155/2018/7964654. View

Rodrigues S, Lopes S, Magro F, Cardoso H, Horta e Vale A, Marques M . Autoimmune hepatitis and anti-tumor necrosis factor alpha therapy: A single center report of 8 cases. World J Gastroenterol. 2015; 21(24):7584-8. PMC: 4481456. DOI: 10.3748/wjg.v21.i24.7584. View

AlSayed M, Elbeah S, El-Desoky M, Elziny S, Megahed A . Polymorphism in Macrophage Migration Inhibitory Factor -173GC in Pediatric Patients with Autoimmune Hepatitis. Pediatr Gastroenterol Hepatol Nutr. 2020; 23(1):63-71. PMC: 6966214. DOI: 10.5223/pghn.2020.23.1.63. View

Zachou K, Weiler-Normann C, Muratori L, Muratori P, Lohse A, Dalekos G . Permanent immunosuppression in SLA/LP-positive autoimmune hepatitis is required although overall response and survival are similar. Liver Int. 2019; 40(2):368-376. DOI: 10.1111/liv.14280. View

Floreani A, Restrepo-Jimenez P, Secchi M, De Martin S, Leung P, Krawitt E . Etiopathogenesis of autoimmune hepatitis. J Autoimmun. 2018; 95:133-143. DOI: 10.1016/j.jaut.2018.10.020. View

10.

Kempinska-Podhorodecka A, Adamowicz M, Chmielarz M, Janik M, Milkiewicz P, Milkiewicz M . Vitamin-D Receptor-Gene Polymorphisms Affect Quality of Life in Patients with Autoimmune Liver Diseases. Nutrients. 2020; 12(8). PMC: 7469002. DOI: 10.3390/nu12082244. View

11.

Kwon J, Hanouneh I, Allende D, Yerian L, Diago T, Eghtesad B . De Novo Autoimmune Hepatitis Following Liver Transplantation. Transplant Proc. 2018; 50(5):1451-1456. DOI: 10.1016/j.transproceed.2018.02.066. View

12.

Duarte-Rey C, Pardo A, Rodriguez-Velosa Y, Mantilla R, Anaya J, Rojas-Villarraga A . HLA class II association with autoimmune hepatitis in Latin America: a meta-analysis. Autoimmun Rev. 2008; 8(4):325-31. DOI: 10.1016/j.autrev.2008.11.005. View

13.

Sasaki T, Suzuki Y, Ishida K, Kakisaka K, Abe H, Sugai T . Autoimmune hepatitis following influenza virus vaccination: Two case reports. Medicine (Baltimore). 2018; 97(30):e11621. PMC: 6078681. DOI: 10.1097/MD.0000000000011621. View

14.

Martinez-Casas O, Diaz-Ramirez G, Marin-Zuluaga J, Munoz-Maya O, Santos O, Donado-Gomez J . Differential characteristics in drug-induced autoimmune hepatitis. JGH Open. 2018; 2(3):97-104. PMC: 6207017. DOI: 10.1002/jgh3.12054. View

15.

Liang M, Liwen Z, Yun Z, Yanbo D, Jianping C . The Imbalance between Foxp3Tregs and Th1/Th17/Th22 Cells in Patients with Newly Diagnosed Autoimmune Hepatitis. J Immunol Res. 2018; 2018:3753081. PMC: 6040251. DOI: 10.1155/2018/3753081. View

16.

Vuerich M, Harshe R, Frank L, Mukherjee S, Gromova B, Csizmadia E . Altered aryl-hydrocarbon-receptor signalling affects regulatory and effector cell immunity in autoimmune hepatitis. J Hepatol. 2020; 74(1):48-57. PMC: 7749856. DOI: 10.1016/j.jhep.2020.06.044. View

17.

McReynolds L, Calvo K, Holland S . Germline GATA2 Mutation and Bone Marrow Failure. Hematol Oncol Clin North Am. 2018; 32(4):713-728. PMC: 6128284. DOI: 10.1016/j.hoc.2018.04.004. View

18.

Webb G, Chen Y, Li K, Neil D, Htun Oo Y, Richter A . Single-gene association between GATA-2 and autoimmune hepatitis: A novel genetic insight highlighting immunologic pathways to disease. J Hepatol. 2016; 64(5):1190-1193. PMC: 4824751. DOI: 10.1016/j.jhep.2016.01.017. View

19.

Liwinski T, Casar C, Ruehlemann M, Bang C, Sebode M, Hohenester S . A disease-specific decline of the relative abundance of Bifidobacterium in patients with autoimmune hepatitis. Aliment Pharmacol Ther. 2020; 51(12):1417-1428. DOI: 10.1111/apt.15754. View

20.

Llovet L, Gratacos-Gines J, Ortiz O, Rodriguez-Tajes S, Lens S, Reverter E . Higher seroprevalence of hepatitis E virus in autoimmune hepatitis: Role of false-positive antibodies. Liver Int. 2019; 40(3):558-564. DOI: 10.1111/liv.14332. View