Healthy Aging Biomarkers: The INSPIRE's Contribution

Overview

Journal J Frailty Aging

Specialties Geriatrics
Physiology

Date 2021 Sep 22

PMID 34549244

Citations 2

Authors

I Ader

L Penicaud

S Andrieu

J R Beard

N Davezac

C Dray

N Fazilleau

P Gourdy

S Guyonnet

R Liblau

A Parini

P Payoux

C Rampon

I Raymond-Letron

Y Rolland

P de Souto Barreto

P Valet

N Vergnolle

F Sierra

B Vellas

L Casteilla

Affiliations

Soon will be listed here.

Abstract

The find solutions for optimizing healthy aging and increase health span is one of the main challenges for our society. A novel healthcare model based on integration and a shift on research and care towards the maintenance of optimal functional levels are now seen as priorities by the WHO. To address this issue, an integrative global strategy mixing longitudinal and experimental cohorts with an innovative transverse understanding of physiological functioning is missing. While the current approach to the biology of aging is mainly focused on parenchymal cells, we propose that age-related loss of function is largely determined by three elements which constitute the general ground supporting the different specific parenchyma: i.e. the stroma, the immune system and metabolism. Such strategy that is implemented in INSPIRE projects can strongly help to find a composite biomarker capable of predicting changes in capacity across the life course with thresholds signalling frailty and care dependence.

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