Modification of the Association by Sex Between the Prenatal Exposure to Di(2-ethylhexyl) Phthalate and Fat Percentage in a Cohort of Mexicans Schoolchildren

Overview

Journal Int J Obes (Lond)

Specialty Endocrinology

Date 2021 Sep 21

PMID 34545176

Citations 1

Authors

Jorge Octavio Acosta Montes

Albino Barraza Villarreal

Isabelle Romieu

Dana Boyd Barr

Karla Cervantes Martinez

Leticia Hernandez Cadena

Affiliations

Soon will be listed here.

Abstract

Introduction: Children's overweight and obesity are global public health problems, children with obesity have grater obesity risk as adults, thus leading to develop cardiometabolic diseases. Previous studies have found positive and significant associations between the exposure to phthalates and body mass index and body composition.

Objective: To evaluate the modification of the association by sex between DEHP exposure during pregnancy and the percentage of body fat in a cohort of Mexican schoolchildren.

Material And Methods: The sample was comprised by children which had previously participated in a POSGRAD longitudinal study. A subsample of 190 mother-children binomials were included. Mothers' DEHP concentrations and its metabolites had been measured in the second trimester of pregnancy: Mono-2-ethylhexyl phthalate (MEHP), Mono-2-ethyl-5-carboxypentyl phthalate (MECPP), Mono-2-ethyl-5-hidroxyhexyl phthalate (MEHHP), and Mono-2-ethyl-5-oxohexyl phthalate (MEOHP). The children's adipose mass was measured at age 8, 9, and 10. Longitudinal data were analyzed using the mixed effects linear regression model, with intercept and random slope, adjusted by important confounders and stratified by sex.

Results: We found a differentiated effect by sex, the exposure to DEHP during pregnancy significantly increases the adipose mass in boys. The average increase was 0.058% (p = 0.02) for every 1% variation in MECPP; 0.047% (p = 0.04) in MEHHP; 0.051% (p = 0.03) in MEOHP, and 0.066% (p = 0.007) in MECPP.

Conclusions: The results suggest an effect differentiated by sex; with boys being the main ones affected by the prenatal exposure to phthalates. However, we cannot rule out effects in girls.

Citing Articles

Midpregnancy Phthalate and Phenol Biomarkers in Relation to Infant Body Composition: The Healthy Start Prospective Cohort.

Stevens D, Starling A, Bommarito P, Keil A, Nakiwala D, Calafat A Environ Health Perspect. 2023; 131(8):87017.

PMID: 37616158 PMC: 10449008. DOI: 10.1289/EHP12500.

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