Analysis of the Regional Difference in the Number of Multi-drug Prescriptions and Its Predictors in Japan, 2015-2018

Overview

Journal BMC Res Notes

Publisher Biomed Central

Specialties Biology
General Medicine

Date 2021 Sep 21

PMID 34544503

Citations 2

Authors

Tasuku Okui

Jinsang Park

Affiliations

Soon will be listed here.

Abstract

Objective: Polypharmacy and multi-drug prescription are major public health problems in Japan, but only a few studies have investigated the regional differences. By revealing regional differences in the multi-drug prescriptions, we can infer regions with high rates of multimorbidity or inappropriate prescribing. This study revealed regional differences in multi-drug prescriptions (the number of simultaneous prescriptions of seven or more internal medicines) and investigated the factors affecting the difference using the National Database of Health Insurance Claims and Specific Health Checkups of Japan data.

Results: The standardized claim ratio (SCR) of the number of multi-drug prescriptions, which corrected the difference in sex and age distribution of prefectures, varied depending on prefectures. A panel data analysis investigating the association between the SCR and explanatory variables (Medical institutions, socioeconomic factors, and physical characteristics of people in prefectures) revealed that the number of public assistance recipients per 1,000 persons was positively and significantly associated with the SCR (Standardized partial regression coefficient = 0.244, p-value = 0.038). In conclusion, regional differences in the number of the multi-drug prescriptions were revealed in Japan, suggesting that public assistance recipients tend to experience multi-drug prescriptions.

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References

Castioni J, Marques-Vidal P, Abolhassani N, Vollenweider P, Waeber G . Prevalence and determinants of polypharmacy in Switzerland: data from the CoLaus study. BMC Health Serv Res. 2017; 17(1):840. PMC: 5740765. DOI: 10.1186/s12913-017-2793-z. View

Fujita M, Sato Y, Nagashima K, Takahashi S, Hata A . Income Related Inequality of Health Care Access in Japan: A Retrospective Cohort Study. PLoS One. 2016; 11(3):e0151690. PMC: 4792389. DOI: 10.1371/journal.pone.0151690. View

Miyaki K, Song Y, Taneichi S, Tsutsumi A, Hashimoto H, Kawakami N . Socioeconomic status is significantly associated with dietary salt intakes and blood pressure in Japanese workers (J-HOPE Study). Int J Environ Res Public Health. 2013; 10(3):980-93. PMC: 3709298. DOI: 10.3390/ijerph10030980. View

Aoki T, Yamamoto Y, Ikenoue T, Onishi Y, Fukuhara S . Multimorbidity patterns in relation to polypharmacy and dosage frequency: a nationwide, cross-sectional study in a Japanese population. Sci Rep. 2018; 8(1):3806. PMC: 5830504. DOI: 10.1038/s41598-018-21917-6. View

Assari S, Bazargan M . Race/Ethnicity, Socioeconomic Status, and Polypharmacy among Older Americans. Pharmacy (Basel). 2019; 7(2). PMC: 6631748. DOI: 10.3390/pharmacy7020041. View

Herr M, Sirven N, Grondin H, Pichetti S, Sermet C . Frailty, polypharmacy, and potentially inappropriate medications in old people: findings in a representative sample of the French population. Eur J Clin Pharmacol. 2017; 73(9):1165-1172. DOI: 10.1007/s00228-017-2276-5. View

Katano H, Koga H, Ozeki N, Otabe K, Mizuno M, Tomita M . Trends in isolated meniscus repair and meniscectomy in Japan, 2011-2016. J Orthop Sci. 2018; 23(4):676-681. DOI: 10.1016/j.jos.2018.04.003. View

Slater N, White S, Venables R, Frisher M . Factors associated with polypharmacy in primary care: a cross-sectional analysis of data from The English Longitudinal Study of Ageing (ELSA). BMJ Open. 2018; 8(3):e020270. PMC: 5857661. DOI: 10.1136/bmjopen-2017-020270. View

Itoh H, Saito T, Nojiri S, Hiratsuka Y, Yokoyama K . National burden of the pharmaceutical cost of wet compresses and its cost predictors: nationwide cross-sectional study in Japan. Health Econ Rev. 2019; 9(1):20. PMC: 6734351. DOI: 10.1186/s13561-019-0238-6. View

10.

Funakoshi M, Azami Y, Matsumoto H, Ikota A, Ito K, Okimoto H . Socioeconomic status and type 2 diabetes complications among young adult patients in Japan. PLoS One. 2017; 12(4):e0176087. PMC: 5402943. DOI: 10.1371/journal.pone.0176087. View

11.

Nguyen T, Ngangue P, Haggerty J, Bouhali T, Fortin M . Multimorbidity, polypharmacy and primary prevention in community-dwelling adults in Quebec: a cross-sectional study. Fam Pract. 2019; 36(6):706-712. PMC: 6859520. DOI: 10.1093/fampra/cmz023. View

12.

Pathirana T, Jackson C . Socioeconomic status and multimorbidity: a systematic review and meta-analysis. Aust N Z J Public Health. 2018; 42(2):186-194. DOI: 10.1111/1753-6405.12762. View

13.

Morio K, Maeda I, Yokota I, Niki K, Murata T, Matsumura Y . Risk Factors for Polypharmacy in Elderly Patients With Cancer Pain. Am J Hosp Palliat Care. 2019; 36(7):598-602. DOI: 10.1177/1049909118824031. View

14.

Nagakura Y, Kato H, Asano S, Jinno Y, Tanei S . The Significant Association between Health Examination Results and Population Health: A Cross-Sectional Ecological Study Using a Nation-Wide Health Checkup Database in Japan. Int J Environ Res Public Health. 2021; 18(2). PMC: 7844624. DOI: 10.3390/ijerph18020836. View

15.

Midao L, Giardini A, Menditto E, Kardas P, Costa E . Polypharmacy prevalence among older adults based on the survey of health, ageing and retirement in Europe. Arch Gerontol Geriatr. 2018; 78:213-220. DOI: 10.1016/j.archger.2018.06.018. View

16.

Nakamura T, Nakamura Y, Saitoh S, Okamura T, Yanagita M, Yoshita K . Relationship Between Socioeconomic Status and the Prevalence of Underweight, Overweight or Obesity in a General Japanese Population: NIPPON DATA2010. J Epidemiol. 2018; 28 Suppl 3:S10-S16. PMC: 5825685. DOI: 10.2188/jea.JE20170249. View

17.

Kojima T, Akishita M, Kameyama Y, Yamaguchi K, Yamamoto H, Eto M . Factors associated with prolonged hospital stay in a geriatric ward of a university hospital in Japan. J Am Geriatr Soc. 2012; 60(6):1190-1. DOI: 10.1111/j.1532-5415.2012.03975.x. View

18.

Penninx B, Lange S . Metabolic syndrome in psychiatric patients: overview, mechanisms, and implications. Dialogues Clin Neurosci. 2018; 20(1):63-73. PMC: 6016046. View

19.

Young E, Pan S, Yap A, Reveles K, Bhakta K . Polypharmacy prevalence in older adults seen in United States physician offices from 2009 to 2016. PLoS One. 2021; 16(8):e0255642. PMC: 8330900. DOI: 10.1371/journal.pone.0255642. View

20.

Pappa E, Kontodimopoulos N, Papadopoulos A, Tountas Y, Niakas D . Prescribed-drug utilization and polypharmacy in a general population in Greece: association with sociodemographic, health needs, health-services utilization, and lifestyle factors. Eur J Clin Pharmacol. 2010; 67(2):185-92. DOI: 10.1007/s00228-010-0940-0. View