A Blood-mimicking Fluid with Cholesterol As Scatter Particles for Wall-less Carotid Artery Phantom Applications

Overview

Journal J Ultrason

Date 2021 Sep 20

PMID 34540276

Citations 3

Authors

Kyermang Kyense Dakok

Mohammed Zubir Matjafri

Nursakinah Suardi

Ammar Anwar Oglat

Seth Ezra Nabasu

Affiliations

Soon will be listed here.

Abstract

At present, there are few scatter particles used in preparing blood-mimicking fluids, such as nylon, sephadex, polystyrene microsphere, and poly(4-methystyrene). In this study, we present cholesterol as a new scatter particle for blood-mimicking fluid preparation. The procedure for the preparation of the proposed blood-mimicking fluid involved the use of propylene glycol, D(+)-Glucose and distilled water to form a ternary mixture fluid, with cholesterol used as scatter particles. Polyethylene glycol was first used as part of the mixture fluid but the acoustic and physical properties were not suitable, leading to its replacement with D(+)-Glucose, which is soluble in water and has a higher density. A common carotid artery wall-less phantom was also produced to assess the flow properties. The prepared blood-mimicking fluid with new scatter particles has a density of 1.067 g/cm, viscosity of 4.1 mPa.s, speed of sound 1600 m/s, and attenuation of 0.192 dB/cm at 5 MHz frequency. Peak systolic velocity, end diastolic velocity and mean velocity measurements were gotten to be 40.2 ± 2.4 cm/s, 9.9 ± 1.4 cm/s, and 24.0 ± 1.8 cm/s, respectively. Based on the results obtained, the blood-mimicking fluid was found suitable for ultrasound applications in carotid artery wall-less phantoms because of its good acoustic and physical properties.

Citing Articles

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References

Rickey D, Picot P, Christopher D, Fenster A . A wall-less vessel phantom for Doppler ultrasound studies. Ultrasound Med Biol. 1995; 21(9):1163-76. DOI: 10.1016/0301-5629(95)00044-5. View

Samavat H, Evans J . An ideal blood mimicking fluid for doppler ultrasound phantoms. J Med Phys. 2011; 31(4):275-8. PMC: 3004103. DOI: 10.4103/0971-6203.29198. View

Yousif M, Holdsworth D, Poepping T . Deriving a blood-mimicking fluid for particle image velocimetry in Sylgard-184 vascular models. Annu Int Conf IEEE Eng Med Biol Soc. 2009; 2009:1412-5. DOI: 10.1109/IEMBS.2009.5334175. View

Boote E, Zagzebski J . Performance tests of Doppler ultrasound equipment with a tissue and blood-mimicking phantom. J Ultrasound Med. 1988; 7(3):137-47. DOI: 10.7863/jum.1988.7.3.137. View

Virani S, Catellier D, Pompeii L, Nambi V, Hoogeveen R, Wasserman B . Relation of cholesterol and lipoprotein parameters with carotid artery plaque characteristics: the Atherosclerosis Risk in Communities (ARIC) carotid MRI study. Atherosclerosis. 2011; 219(2):596-602. PMC: 3226845. DOI: 10.1016/j.atherosclerosis.2011.08.001. View

Oates C . Towards an ideal blood analogue for Doppler ultrasound phantoms. Phys Med Biol. 1991; 36(11):1433-42. DOI: 10.1088/0031-9155/36/11/003. View

Oglat A, Matjafri M, Suardi N, Oqlat M, Abdelrahman M, Oqlat A . A Review of Medical Doppler Ultrasonography of Blood Flow in General and Especially in Common Carotid Artery. J Med Ultrasound. 2018; 26(1):3-13. PMC: 6029191. DOI: 10.4103/JMU.JMU_11_17. View

Law Y, Johnston K, Routh H, COBBOLD R . On the design and evaluation of a steady flow model for Doppler ultrasound studies. Ultrasound Med Biol. 1989; 15(5):505-16. DOI: 10.1016/0301-5629(89)90103-8. View

Hoskins P, Anderson T, McDicken W . A computer controlled flow phantom for generation of physiological Doppler waveforms. Phys Med Biol. 1989; 34(11):1709-17. DOI: 10.1088/0031-9155/34/11/018. View

10.

Lubbers J . Application of a new blood-mimicking fluid in a flow Doppler test object. Eur J Ultrasound. 2000; 9(3):267-76. DOI: 10.1016/s0929-8266(99)00035-x. View

11.

Oglat A, Suardi N, Matjafri M, Oqlat M, Abdelrahman M, Oqlat A . A Review of Suspension-Scattered Particles Used in Blood-Mimicking Fluid for Doppler Ultrasound Imaging. J Med Ultrasound. 2018; 26(2):68-76. PMC: 6029209. DOI: 10.4103/JMU.JMU_1_17. View

12.

Ramnarine K, Hoskins P, Routh H, Davidson F . Doppler backscatter properties of a blood-mimicking fluid for Doppler performance assessment. Ultrasound Med Biol. 1999; 25(1):105-10. DOI: 10.1016/s0301-5629(98)00139-2. View

13.

Hussain R, Duerinckx A, Tessler F, Grant E . Assurance of consistent peak-velocity measurements with a variety of duplex Doppler instruments. Radiology. 1990; 177(1):265-72. DOI: 10.1148/radiology.177.1.2204967. View

14.

Newhouse V, Nathan R, Hertzler L . A proposed standard target for ultrasound Doppler gain calibration. Ultrasound Med Biol. 1982; 8(3):313-6. DOI: 10.1016/0301-5629(82)90038-2. View

15.

Douville Y, Johnston K, Kassam M, Zuech P, COBBOLD R, Jares A . An in vitro model and its application for the study of carotid Doppler spectral broadening. Ultrasound Med Biol. 1983; 9(4):347-56. DOI: 10.1016/0301-5629(83)90087-x. View

16.

Hoskins P, Loupas T, McDicken W . A comparison of the Doppler spectra from human blood and artificial blood used in a flow phantom. Ultrasound Med Biol. 1990; 16(2):141-7. DOI: 10.1016/0301-5629(90)90142-y. View

17.

Ramnarine K, Nassiri D, Hoskins P, Lubbers J . Validation of a new blood-mimicking fluid for use in Doppler flow test objects. Ultrasound Med Biol. 1998; 24(3):451-9. DOI: 10.1016/s0301-5629(97)00277-9. View

18.

Hein I, OBrien Jr W . A flexible blood flow phantom capable of independently producing constant and pulsatile flow with a predictable spatial flow profile for ultrasound flow measurement validations. IEEE Trans Biomed Eng. 1992; 39(11):1111-22. DOI: 10.1109/10.168687. View

19.

Holdsworth D, Rickey D, Drangova M, Miller D, Fenster A . Computer-controlled positive displacement pump for physiological flow simulation. Med Biol Eng Comput. 1991; 29(6):565-70. DOI: 10.1007/BF02446086. View

20.

Zhou X, Kenwright D, Wang S, Hossack J, Hoskins P . Fabrication of Two Flow Phantoms for Doppler Ultrasound Imaging. IEEE Trans Ultrason Ferroelectr Freq Control. 2016; 64(1):53-65. DOI: 10.1109/TUFFC.2016.2634919. View