The Effect of Local Renin Angiotensin System in the Common Types of Cancer

Overview

Journal Front Endocrinol (Lausanne)

Specialty Endocrinology

Date 2021 Sep 20

PMID 34539580

Citations 23

Authors

Moudhi Almutlaq

Abir Abdullah Alamro

Hassan S Alamri

Amani Ahmed Alghamdi

Tlili Barhoumi

Affiliations

Soon will be listed here.

Abstract

The Renin Angiotensin System (RAS) is a hormonal system that is responsible for blood pressure hemostasis and electrolyte balance. It is implicated in cancer hallmarks because it is expressed locally in almost all of the body's tissues. In this review, current knowledge on the effect of local RAS in the common types of cancer such as breast, lung, liver, prostate and skin cancer is summarised. The mechanisms by which RAS components could increase or decrease cancer activity are also discussed. In addition to the former, this review explores how the administration of AT1R blockers and ACE inhibitors drugs intervene with cancer therapy and contribute to the outcomes of cancer.

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