Integrins in the Regulation of Mesenchymal Stem Cell Differentiation by Mechanical Signals

Overview

Journal Stem Cell Rev Rep

Publisher Springer

Specialty Cell Biology

Date 2021 Sep 18

PMID 34536203

Citations 14

Authors

Lei Wang

Fuwen Zheng

Ruixue Song

Lequan Zhuang

Ming Yang

Jian Suo

Lisha Li

Affiliations

Soon will be listed here.

Abstract

Mesenchymal stem cells (MSCs) can sense and convert mechanical stimuli signals into a chemical response. Integrins are involved in the mechanotransduction from inside to outside and from outside to inside, and ultimately affect the fate of MSCs responding to different mechanical signals. Different integrins participate in different signaling pathways to regulate MSCs multi-differentiation. In this review, we summarize the latest advances in the effects of mechanical signals on the differentiation of MSCs, the importance of integrins in mechanotransduction, the relationship between integrin heterodimers and different mechanical signals, and the interaction among mechanical signals. We put forward our views on the prospect and challenges of developing mechanical biology in tissue engineering and regenerative medicine.

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References

Horwitz E, Le Blanc K, Dominici M, Mueller I, Slaper-Cortenbach I, Marini F . Clarification of the nomenclature for MSC: The International Society for Cellular Therapy position statement. Cytotherapy. 2005; 7(5):393-5. DOI: 10.1080/14653240500319234. View

Guilak F, Mow V . The mechanical environment of the chondrocyte: a biphasic finite element model of cell-matrix interactions in articular cartilage. J Biomech. 2000; 33(12):1663-73. View

Fletcher D, Mullins R . Cell mechanics and the cytoskeleton. Nature. 2010; 463(7280):485-92. PMC: 2851742. DOI: 10.1038/nature08908. View

Gonzalez-Cruz R, Fonseca V, Darling E . Cellular mechanical properties reflect the differentiation potential of adipose-derived mesenchymal stem cells. Proc Natl Acad Sci U S A. 2012; 109(24):E1523-9. PMC: 3386052. DOI: 10.1073/pnas.1120349109. View

Shattil S, Kim C, Ginsberg M . The final steps of integrin activation: the end game. Nat Rev Mol Cell Biol. 2010; 11(4):288-300. PMC: 3929966. DOI: 10.1038/nrm2871. View

Ginsberg M . Integrin activation. BMB Rep. 2014; 47(12):655-9. PMC: 4345508. DOI: 10.5483/bmbrep.2014.47.12.241. View

Li J, Springer T . Integrin extension enables ultrasensitive regulation by cytoskeletal force. Proc Natl Acad Sci U S A. 2017; 114(18):4685-4690. PMC: 5422820. DOI: 10.1073/pnas.1704171114. View

Shoemaker B, Portman J, Wolynes P . Speeding molecular recognition by using the folding funnel: the fly-casting mechanism. Proc Natl Acad Sci U S A. 2000; 97(16):8868-73. PMC: 16787. DOI: 10.1073/pnas.160259697. View

Horton E, Humphries J, James J, Jones M, Askari J, Humphries M . The integrin adhesome network at a glance. J Cell Sci. 2016; 129(22):4159-4163. PMC: 5117201. DOI: 10.1242/jcs.192054. View

10.

Klapholz B, Brown N . Talin - the master of integrin adhesions. J Cell Sci. 2017; 130(15):2435-2446. DOI: 10.1242/jcs.190991. View

11.

Sun Z, Costell M, Fassler R . Integrin activation by talin, kindlin and mechanical forces. Nat Cell Biol. 2019; 21(1):25-31. DOI: 10.1038/s41556-018-0234-9. View

12.

Martino M, Mochizuki M, Rothenfluh D, Rempel S, Hubbell J, Barker T . Controlling integrin specificity and stem cell differentiation in 2D and 3D environments through regulation of fibronectin domain stability. Biomaterials. 2008; 30(6):1089-97. PMC: 2718049. DOI: 10.1016/j.biomaterials.2008.10.047. View

13.

Cooper J, Giancotti F . Integrin Signaling in Cancer: Mechanotransduction, Stemness, Epithelial Plasticity, and Therapeutic Resistance. Cancer Cell. 2019; 35(3):347-367. PMC: 6684107. DOI: 10.1016/j.ccell.2019.01.007. View

14.

Becchetti A, Petroni G, Arcangeli A . Ion Channel Conformations Regulate Integrin-Dependent Signaling. Trends Cell Biol. 2019; 29(4):298-307. DOI: 10.1016/j.tcb.2018.12.005. View

15.

Xiao E, Yang H, Gan Y, Duan D, He L, Guo Y . Brief reports: TRPM7 Senses mechanical stimulation inducing osteogenesis in human bone marrow mesenchymal stem cells. Stem Cells. 2014; 33(2):615-21. DOI: 10.1002/stem.1858. View

16.

Arcangeli A, Becchetti A . Complex functional interaction between integrin receptors and ion channels. Trends Cell Biol. 2006; 16(12):631-9. DOI: 10.1016/j.tcb.2006.10.003. View

17.

Ron A, Azeloglu E, Calizo R, Hu M, Bhattacharya S, Chen Y . Cell shape information is transduced through tension-independent mechanisms. Nat Commun. 2017; 8(1):2145. PMC: 5732205. DOI: 10.1038/s41467-017-02218-4. View

18.

McIlhenny S, Hager E, Grabo D, Dimatteo C, Shapiro I, Tulenko T . Linear shear conditioning improves vascular graft retention of adipose-derived stem cells by upregulation of the alpha5beta1 integrin. Tissue Eng Part A. 2009; 16(1):245-55. PMC: 2810996. DOI: 10.1089/ten.TEA.2009.0238. View

19.

Bachle M, Kohal R . A systematic review of the influence of different titanium surfaces on proliferation, differentiation and protein synthesis of osteoblast-like MG63 cells. Clin Oral Implants Res. 2004; 15(6):683-92. DOI: 10.1111/j.1600-0501.2004.01054.x. View

20.

Reilly G, Engler A . Intrinsic extracellular matrix properties regulate stem cell differentiation. J Biomech. 2009; 43(1):55-62. DOI: 10.1016/j.jbiomech.2009.09.009. View