Exercise Improves Health-related Quality of Life Sleep and Fatigue Domains in Adult High- and Low-grade Glioma Patients

Overview

Journal Support Care Cancer

Specialties Critical Care
Oncology

Date 2021 Sep 17

PMID 34532753

Citations 6

Authors

Zachary Miklja

Nicolette Gabel

David Altshuler

Lin Wang

Shawn L Hervey-Jumper

Sean Smith

Affiliations

Soon will be listed here.

Abstract

Purpose: The impact of exercise on health-related quality of life (HRQOL) in patients with glioma remains unknown. We hypothesized that glioma patients with low exercise tolerance experience more distress in HRQOL sleep and fatigue domains than patients with high tolerance to exercise.

Methods: Thirty-eight male and female patients with low- or high-grade glioma treated at a single tertiary care institution participated. Patients completed a validated telephone survey to determine their exercise habits before and following diagnosis. An unpaired t-test was run to measure the interaction between exercise tolerances on HRQOL functional and impairment domains.

Results: Those with low pre-morbid physical activity levels had more distress in HRQOL sleep and fatigue domains. The effects were independent of plasma brain-derived neurotrophic factor (BDNF) levels and the degree of exercise did not appear to impact plasma BDNF in adult glioma patients.

Conclusions: The aim of this study was to examine the significance of exercise habits on perioperative functional outcomes in patients with low-grade or high-grade glioma. We found that glioma patients with low tolerance to exercise had more sleep disturbances and greater fatigue than glioma patients with high tolerance to exercise. Furthermore, exercise tolerance in the adult glioma population does not appear to impact plasma BDNF secretion.

Citing Articles

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Treatment Options for IDH-Mutant Malignant Gliomas.

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Physical therapy enhances physical and functional abilities in a female patient with gliomatosis cerebri.

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Pieczynska A, Zasadzka E, Pilarska A, Procyk D, Adamska K, Hojan K J Clin Med. 2023; 12(21).

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