Understanding the Pathogenesis of Infectious Diseases by Single-cell RNA Sequencing

Overview

Journal Microb Cell

Specialty Microbiology

Date 2021 Sep 16

PMID 34527720

Citations 5

Authors

Wanqiu Huang

Danni Wang

Yu-Feng Yao

Affiliations

Soon will be listed here.

Abstract

Infections are highly orchestrated and dynamic processes, which involve both pathogen and host. Transcriptional profiling at the single-cell level enables the analysis of cell diversity, heterogeneity of the immune response, and detailed molecular mechanisms underlying infectious diseases caused by bacteria, viruses, fungi, and parasites. Herein, we highlight recent remarkable advances in single-cell RNA sequencing (scRNA-seq) technologies and their applications in the investigation of host-pathogen interactions, current challenges and potential prospects for disease treatment are discussed as well. We propose that with the aid of scRNA-seq, the mechanism of infectious diseases will be further revealed thus inspiring the development of novel interventions and therapies.

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