Combined Signature of the Urinary Microbiome and Metabolome in Patients With Interstitial Cystitis

Overview

Journal Front Cell Infect Microbiol

Specialties Cell Biology
Infectious Diseases
Microbiology

Date 2021 Sep 16

PMID 34527602

Citations 8

Authors

Hewei Xu

Nebiyu Elias Tamrat

Jie Gao

Jie Xu

Yiduo Zhou

Sicong Zhang

Zhengsen Chen

Yunpeng Shao

Liucheng Ding

Baixin Shen

Zhongqing Wei

Affiliations

Soon will be listed here.

Abstract

Interstitial cystitis (IC) is a clinical syndrome characterized by frequency, urgency, and bladder pain or pelvic pain; however, the underlying pathophysiological mechanisms and diagnostic markers are unknown. In this study, microbiome and metabolome analysis were used to explain the urine signatures of IC patients. Urine samples from 20 IC patients and 22 control groups were analyzed by using 16S rRNA sequence and liquid chromatography coupled with mass spectrometry. Four opportunistic pathogen genera, including Serratia, Brevibacterium, Porphyromonas, and Citrobacter, were significantly upregulated in IC group. The altered metabolite signatures of the metabolome may be related to sphingosine metabolism, amino acid metabolism, and fatty acid biosynthesis. Meanwhile, the associations were observed between different metabolites and microbiomes of IC. The present study suggests that the combined signatures of IC in urine microbiome and metabolome may become its prospective diagnostic markers.

Citing Articles

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