Astrocyte-Derived Extracellular Vesicles (ADEVs): Deciphering Their Influences in Aging

Overview

Journal Aging Dis

Specialty Geriatrics

Date 2021 Sep 16

PMID 34527422

Citations 8

Authors

Megan E Rouillard

Pearl A Sutter

Olivia R Durham

Cory M Willis

Stephen J Crocker

Affiliations

Soon will be listed here.

Abstract

Astrocytes are an abundant and dynamic glial cell exclusive to the central nervous system (CNS). In the context of injury, inflammation, and/or diseases of the nervous system, astrocyte responses, termed reactive astrogliosis, are a recognized pathological feature across a range of conditions and diseases. However, the impact of reactive astrogliosis is not uniform and varies by context and duration (time). In recent years, extracellular communication between glial cells via extracellular vesicles (EVs) has garnered interest as a process connected with reactive astrogliosis. In this review, we relate recent findings on astrocyte-derived extracellular vesicles (ADEVs) with a focus on factors that can influence the effects of ADEVs and identified age related changes in the function of ADEVs. Additionally, we will discuss the current limitations of existing experimental approaches and identify questions that highlight areas for growth in this field, which will continue to enhance our understanding of ADEVs in age-associated processes.

Citing Articles

A convenient model of serum-induced reactivity of human astrocytes to investigate astrocyte-derived extracellular vesicles.

White K, Bailey H, Shaw B, Geiszler P, Mesquita-Ribeiro R, Scott D Front Cell Neurosci. 2024; 18:1414142.

PMID: 38915876 PMC: 11195030. DOI: 10.3389/fncel.2024.1414142.

Emerging Roles of Extracelluar Vesicles Derived from Bacteria, Mammalian or Plant Cells in the Pathogenesis and Clinical Application of Neurodegenerative Diseases.

Li Y, Zhou C, Liu H, Cai T, Fan H Biomolecules. 2024; 14(3).

PMID: 38540732 PMC: 10968246. DOI: 10.3390/biom14030312.

Emergence of Extracellular Vesicles as "Liquid Biopsy" for Neurological Disorders: Boom or Bust.

Kumar A, Nader M, Deep G Pharmacol Rev. 2024; 76(2):199-227.

PMID: 38351075 PMC: 10877757. DOI: 10.1124/pharmrev.122.000788.

Extracellular Vesicles in the Central Nervous System: A Novel Mechanism of Neuronal Cell Communication.

Filannino F, Panaro M, Benameur T, Pizzolorusso I, Porro C Int J Mol Sci. 2024; 25(3).

PMID: 38338906 PMC: 10855168. DOI: 10.3390/ijms25031629.

Oxygen glucose deprivation-pretreated astrocyte-derived exosomes attenuates intracerebral hemorrhage (ICH)-induced BBB disruption through miR-27a-3p /ARHGAP25/Wnt/β-catenin axis.

Hou Y, Xie Y, Liu X, Chen Y, Zhou F, Yang B Fluids Barriers CNS. 2024; 21(1):8.

PMID: 38243347 PMC: 10799414. DOI: 10.1186/s12987-024-00510-2.

References

Luarte A, Henzi R, Fernandez A, Gaete D, Cisternas P, Pizarro M . Astrocyte-Derived Small Extracellular Vesicles Regulate Dendritic Complexity through miR-26a-5p Activity. Cells. 2020; 9(4). PMC: 7226994. DOI: 10.3390/cells9040930. View

Whittemore K, Vera E, Martinez-Nevado E, Sanpera C, Blasco M . Telomere shortening rate predicts species life span. Proc Natl Acad Sci U S A. 2019; 116(30):15122-15127. PMC: 6660761. DOI: 10.1073/pnas.1902452116. View

Skog J, Wurdinger T, van Rijn S, Meijer D, Gainche L, Sena-Esteves M . Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers. Nat Cell Biol. 2008; 10(12):1470-6. PMC: 3423894. DOI: 10.1038/ncb1800. View

Samantaray S, Knaryan V, Shields D, Cox A, Haque A, Banik N . Inhibition of Calpain Activation Protects MPTP-Induced Nigral and Spinal Cord Neurodegeneration, Reduces Inflammation, and Improves Gait Dynamics in Mice. Mol Neurobiol. 2015; 52(2):1054-66. PMC: 4558265. DOI: 10.1007/s12035-015-9255-6. View

Sproviero D, La Salvia S, Giannini M, Crippa V, Gagliardi S, Bernuzzi S . Pathological Proteins Are Transported by Extracellular Vesicles of Sporadic Amyotrophic Lateral Sclerosis Patients. Front Neurosci. 2018; 12:487. PMC: 6060258. DOI: 10.3389/fnins.2018.00487. View

Haraszti R, Didiot M, Sapp E, Leszyk J, Shaffer S, Rockwell H . High-resolution proteomic and lipidomic analysis of exosomes and microvesicles from different cell sources. J Extracell Vesicles. 2016; 5:32570. PMC: 5116062. DOI: 10.3402/jev.v5.32570. View

Schanzer A, Wachs F, Wilhelm D, Acker T, Cooper-Kuhn C, Beck H . Direct stimulation of adult neural stem cells in vitro and neurogenesis in vivo by vascular endothelial growth factor. Brain Pathol. 2004; 14(3):237-48. PMC: 8096047. DOI: 10.1111/j.1750-3639.2004.tb00060.x. View

Dinkins M, Dasgupta S, Wang G, Zhu G, Bieberich E . Exosome reduction in vivo is associated with lower amyloid plaque load in the 5XFAD mouse model of Alzheimer's disease. Neurobiol Aging. 2014; 35(8):1792-800. PMC: 4035236. DOI: 10.1016/j.neurobiolaging.2014.02.012. View

Karpman D, Stahl A, Arvidsson I . Extracellular vesicles in renal disease. Nat Rev Nephrol. 2017; 13(9):545-562. DOI: 10.1038/nrneph.2017.98. View

10.

van der Pol E, Coumans F, Grootemaat A, Gardiner C, Sargent I, Harrison P . Particle size distribution of exosomes and microvesicles determined by transmission electron microscopy, flow cytometry, nanoparticle tracking analysis, and resistive pulse sensing. J Thromb Haemost. 2014; 12(7):1182-92. DOI: 10.1111/jth.12602. View

11.

Liddelow S, Marsh S, Stevens B . Microglia and Astrocytes in Disease: Dynamic Duo or Partners in Crime?. Trends Immunol. 2020; 41(9):820-835. DOI: 10.1016/j.it.2020.07.006. View

12.

Coppe J, Desprez P, Krtolica A, Campisi J . The senescence-associated secretory phenotype: the dark side of tumor suppression. Annu Rev Pathol. 2010; 5:99-118. PMC: 4166495. DOI: 10.1146/annurev-pathol-121808-102144. View

13.

Abbott N . Astrocyte-endothelial interactions and blood-brain barrier permeability. J Anat. 2002; 200(6):629-38. PMC: 1570746. DOI: 10.1046/j.1469-7580.2002.00064.x. View

14.

Dragovic R, Collett G, Hole P, Ferguson D, Redman C, Sargent I . Isolation of syncytiotrophoblast microvesicles and exosomes and their characterisation by multicolour flow cytometry and fluorescence Nanoparticle Tracking Analysis. Methods. 2015; 87:64-74. PMC: 4641874. DOI: 10.1016/j.ymeth.2015.03.028. View

15.

Feiler M, Strobel B, Freischmidt A, Helferich A, Kappel J, Brewer B . TDP-43 is intercellularly transmitted across axon terminals. J Cell Biol. 2015; 211(4):897-911. PMC: 4657165. DOI: 10.1083/jcb.201504057. View

16.

Wang Z, Deng Z, Dahmane N, Tsai K, Wang P, Williams D . Telomeric repeat-containing RNA (TERRA) constitutes a nucleoprotein component of extracellular inflammatory exosomes. Proc Natl Acad Sci U S A. 2015; 112(46):E6293-300. PMC: 4655533. DOI: 10.1073/pnas.1505962112. View

17.

Mulcahy L, Pink R, Carter D . Routes and mechanisms of extracellular vesicle uptake. J Extracell Vesicles. 2014; 3. PMC: 4122821. DOI: 10.3402/jev.v3.24641. View

18.

Lopez-Otin C, Blasco M, Partridge L, Serrano M, Kroemer G . The hallmarks of aging. Cell. 2013; 153(6):1194-217. PMC: 3836174. DOI: 10.1016/j.cell.2013.05.039. View

19.

van der Pol E, van Gemert M, Sturk A, Nieuwland R, van Leeuwen T . Single vs. swarm detection of microparticles and exosomes by flow cytometry. J Thromb Haemost. 2012; 10(5):919-30. DOI: 10.1111/j.1538-7836.2012.04683.x. View

20.

Alique M, Ruiz-Torres M, Bodega G, Noci M, Troyano N, Bohorquez L . Microvesicles from the plasma of elderly subjects and from senescent endothelial cells promote vascular calcification. Aging (Albany NY). 2017; 9(3):778-789. PMC: 5391231. DOI: 10.18632/aging.101191. View