Pulmonary Infection Induces Persistent, Pathogen-specific Lipidomic Changes Influencing Trained Immunity

Overview

Journal iScience

Publisher Cell Press

Date 2021 Sep 15

PMID 34522865

Citations 4

Authors

Lydia M Roberts

Benjamin Schwarz

Emily Speranza

Ian Leighton

Tara Wehrly

Sonja Best

Catharine M Bosio

Affiliations

Soon will be listed here.

Abstract

Resolution of infection results in development of trained innate immunity which is typically beneficial for defense against unrelated secondary infection. Epigenetic changes including modification of histones via binding of various polar metabolites underlie the establishment of trained innate immunity. Therefore, host metabolism and this response are intimately linked. However, little is known regarding the influence of lipids on the development and function of trained immunity. Utilizing two models of pulmonary bacterial infection combined with multi-omic approaches, we identified persistent, pathogen-specific changes to the lung lipidome that correlated with differences in the trained immune response against a third unrelated pathogen. Further, we establish the specific cellular populations in the lung that contribute to this altered lipidome. Together these results expand our understanding of the pulmonary trained innate immune response and the contributions of host lipids in informing that response.

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