Invasive Ductal Carcinoma and Small Lymphocytic Lymphoma/chronic Lymphocytic Leukemia Manifesting As a Collision Breast Tumor: A Case Report and Literature Review

Overview

Journal Open Life Sci

Specialty Biology

Date 2021 Sep 15

PMID 34522780

Authors

Xiaowen Chen

Jianli Chen

Sihai Liao

Yuwen Cao

Affiliations

Soon will be listed here.

Abstract

Collision breast tumors, consisting of breast cancer (BC) and non-Hodgkin's lymphoma (NHL), are extremely rare. Here we report the case of a 64-year-old woman with a collision tumor in her left breast mass that was composed of invasive ductal carcinoma and small lymphocytic lymphoma/chronic lymphocytic leukemia. In addition, we reviewed the published comparable English-language literature. Collision breast tumor composed of BC and NHL is extremely rare. For that reason, there is a lack of consensus about the underlying mechanism, and diagnosing it without delay remains a complex clinical challenge. We found that post-menopausal, age-related estrogen levels changes and Epstein-Barr virus infection are possible pathogenic factors. However, the symptoms are almost identical, and it is difficult to distinguish a simple breast tumor from a breast collision tumor. In this study, we reviewed the clinical features of all patients with BC and NHL colliding breast tumors; this information might enable early identification and prevention of misdiagnosis.

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