The Role and Validity of Diagnostic Biomarkers in Late-Onset Neonatal Sepsis

Overview

Journal Cureus

Specialty Biomedical Engineering

Date 2021 Sep 15

PMID 34522543

Citations 5

Authors

Patience Mwesigye

Fizza Rizwan

Niazy Alassaf

Rizwan Khan

Affiliations

Soon will be listed here.

Abstract

Sepsis remains a leading cause of mortality in the neonatal population, and currently, there is still no consensus on an accurate biomarker that can aid prompt diagnosis. This review focuses on studies investigating biomarkers for late-onset neonatal sepsis specifically. We discuss the current evidence for traditionally used biomarkers and present recent developments on more novel markers. Suitable articles were selected from PubMed, Embase, Medline, Cochrane Handbook of Systematic Reviews, and ScienceDirect. Inclusion criteria were studies published from 2010 to 2020. Exclusion criteria were animal model-based studies. Keywords in search strategy were late-onset neonatal sepsis + biomarkers + diagnosis. Evidence is growing increasingly weak for commonly studied biomarkers such as C-reactive protein (CRP) and procalcitonin (PCT). Levels of markers such as Serum Amyloid A and Neutrophil CD64 increase more rapidly post-onset of infection compared to CRP. Moreover, this review found that the more novel biomarkers discussed such as presepsin and endocan may show superior and more promising potential as diagnostic markers. However, larger studies over multicenters are deemed essential to ascertain the ideal biomarker.

Citing Articles

Understanding the Difficulties in Diagnosing Neonatal Sepsis: Assessing the Role of Sepsis Biomarkers.

Lungu N, Jura A, Popescu D, Horhat F, Manea A, Boia M J Crit Care Med (Targu Mures). 2025; 10(4):316-328.

PMID: 39829727 PMC: 11740700. DOI: 10.2478/jccm-2024-0039.

Early Diagnostic Markers of Late-Onset Neonatal Sepsis.

Gatseva P, Blazhev A, Yordanov Z, Atanasova V Pediatr Rep. 2023; 15(3):548-559.

PMID: 37755410 PMC: 10535522. DOI: 10.3390/pediatric15030050.

The Role of Coagulase-Negative Staphylococci Biofilms on Late-Onset Sepsis: Current Challenges and Emerging Diagnostics and Therapies.

Franca A Antibiotics (Basel). 2023; 12(3).

PMID: 36978421 PMC: 10044083. DOI: 10.3390/antibiotics12030554.

Fighting Antimicrobial Resistance in Neonatal Intensive Care Units: Rational Use of Antibiotics in Neonatal Sepsis.

Rallis D, Giapros V, Serbis A, Kosmeri C, Baltogianni M Antibiotics (Basel). 2023; 12(3).

PMID: 36978375 PMC: 10044400. DOI: 10.3390/antibiotics12030508.

Antimicrobial Peptides in Early-Life Host Defense, Perinatal Infections, and Necrotizing Enterocolitis-An Update.

Agakidou E, Agakidis C, Kontou A, Chotas W, Sarafidis K J Clin Med. 2022; 11(17).

PMID: 36079001 PMC: 9457252. DOI: 10.3390/jcm11175074.

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