Biomarker-Based Management of AKI: Fact or Fantasy?
Overview
Affiliations
New biomarkers for acute kidney injury (AKI) have improved our understanding of the etiology and pathogenesis of AKI. Depending on their origin, function, and kinetic profile, biomarkers have a role in screening, diagnosis, prognostication, and monitoring of AKI. This offers opportunities to improve the management of AKI, but concerns and limitations remain. In this review, we summarize the current role of new AKI biomarkers in the management of AKI and outline some of the ongoing limitations and challenges.
Absence of Kidney Tubular Injury in Patients With Acute Heart Failure With Acute Kidney Injury.
Duff S, Wettersten N, Horiuchi Y, Van Veldhuisen D, Raturi S, Irwin R Circ Heart Fail. 2024; 17(11):e011751.
PMID: 39421939 PMC: 11573103. DOI: 10.1161/CIRCHEARTFAILURE.123.011751.
Biomarkers in acute kidney injury.
Ostermann M, Legrand M, Meersch M, Srisawat N, Zarbock A, Kellum J Ann Intensive Care. 2024; 14(1):145.
PMID: 39279017 PMC: 11402890. DOI: 10.1186/s13613-024-01360-9.
Evaluating Progression Risk in Patients With Immunoglobulin A Nephropathy.
Cattran D, Floege J, Coppo R Kidney Int Rep. 2023; 8(12):2515-2528.
PMID: 38106572 PMC: 10719597. DOI: 10.1016/j.ekir.2023.09.020.
Hypernatremia: Epidemiology and Predictive Role in Emerging and Established Acute Kidney Injury.
Jansch C, Matyukhin I, Marahrens M, Lehmann R, Khader B, Ritter O J Clin Med Res. 2023; 15(8-9):399-405.
PMID: 37822854 PMC: 10563820. DOI: 10.14740/jocmr4990.
Improvement of composite kidney outcomes by AKI care bundles: a systematic review and meta-analysis.
See C, Pan H, Chen J, Wu C, Liao H, Huang Y Crit Care. 2023; 27(1):390.
PMID: 37814334 PMC: 10563300. DOI: 10.1186/s13054-023-04641-0.