Homeostasis Disrupted and Restored-A Fresh Look at the Mechanism and Treatment of Obesity During COVID-19

Overview

Journal Front Cardiovasc Med

Specialty Cardiology & Vascular Diseases

Date 2021 Sep 13

PMID 34513959

Citations 1

Authors

Jacqueline Dickey

Camelia Davtyan

David Davtyan

Heinrich Taegtmeyer

Affiliations

Soon will be listed here.

Abstract

The prevalence of obesity in the United States approaches half of the adult population. The COVID-19 pandemic endangers the health of obese individuals. In addition, the metabolic syndrome poses a challenge to the health of obese adults. Bariatric surgery and diet restore metabolic homeostasis in obese individuals; however, it is still unclear which strategy is most effective. For example, intermittent fasting improves insulin sensitivity and diet alone decreases visceral adipose tissue at a disproportionately high rate compared to weight loss. Bariatric surgery causes rapid remission of type 2 diabetes and increases incretins for long-term remission of insulin resistance before meaningful weight loss has occurred. Malabsorptive surgeries have provided insight into the mechanism of altering metabolic parameters, but strong evidence to determine the duration of their effects is yet to be established. When determining the best method of weight loss, metabolic parameters, target weight loss, and risk-benefit analysis must be considered carefully. In this review, we address the pros and cons for the optimal way to restore metabolic homeostasis.

Citing Articles

Impact of COVID-19 on the Destiny of Bariatric Patients.

Gualtieri P, Marchetti M, Di Renzo L, De Santis G, Palma R, Colica C Nutrients. 2023; 15(1).

PMID: 36615820 PMC: 9824221. DOI: 10.3390/nu15010163.

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