Preclinical and Clinical Progress for HDAC As a Putative Target for Epigenetic Remodeling and Functionality of Immune Cells

Overview

Journal Int J Biol Sci

Specialty Biology

Date 2021 Sep 13

PMID 34512154

Citations 8

Authors

Sijia Zhang

Lingjun Zhan

Xue Li

Zhenhong Yang

Yumin Luo

Haiping Zhao

Affiliations

Soon will be listed here.

Abstract

Genetic changes are difficult to reverse; thus, epigenetic aberrations, including changes in DNA methylation, histone modifications, and noncoding RNAs, with potential reversibility, have attracted attention as pharmaceutical targets. The current paradigm is that histone deacetylases (HDACs) regulate gene expression via deacetylation of histone and nonhistone proteins or by forming corepressor complexes with transcription factors. The emergence of epigenetic tools related to HDACs can be used as diagnostic and therapeutic markers. HDAC inhibitors that block specific or a series of HDACs have proven to be a powerful therapeutic treatment for immune-related diseases. Here, we summarize the various roles of HDACs and HDAC inhibitors in the development and function of innate and adaptive immune cells and their implications for various diseases and therapies.

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