Modifying Strategies for SDF-1/CXCR4 Interaction During Mesenchymal Stem Cell Transplantation

Overview

Journal Gen Thorac Cardiovasc Surg

Specialties Cardiology & Vascular Diseases
General Surgery
Pulmonary Medicine

Date 2021 Sep 12

PMID 34510332

Citations 15

Authors

Qin Jiang

Keli Huang

Fang Lu

Shaoping Deng

Zhenglin Yang

Shengshou Hu

Affiliations

Soon will be listed here.

Abstract

Mesenchymal stem cell (MSC) transplantation is regarded as a promising candidate for the treatment of ischaemic heart disease. The major hurdles for successful clinical translation of MSC therapy are poor survival, retention, and engraftment in the infarcted heart. Stromal cell-derived factor-1/chemokine receptor 4 (SDF-1/CXCR4) constitutes one of the most efficient chemokine/chemokine receptor pairs regarding cell homing. In this review, we mainly focused on previous studies on how to regulate the SDF-1/CXCR4 interaction through various priming strategies to maximize the efficacy of mesenchymal stem cell transplantation on ischaemic hearts or to facilitate the required effects. The strengthened measures for enhancing the therapeutic efficacy of the SDF-1/CXCR4 interaction for mesenchymal stem cell transplantation included the combination of chemokines and cytokines, hormones and drugs, biomaterials, gene engineering, and hypoxia. The priming strategies on recipients for stem cell transplantation included ischaemic conditioning and device techniques.

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References

Melling G, Carollo E, Conlon R, Simpson J, Carter D . The Challenges and Possibilities of Extracellular Vesicles as Therapeutic Vehicles. Eur J Pharm Biopharm. 2019; 144:50-56. DOI: 10.1016/j.ejpb.2019.08.009. View

Hou M, Yang K, Zhang H, Zhu W, Duan F, Wang H . Transplantation of mesenchymal stem cells from human bone marrow improves damaged heart function in rats. Int J Cardiol. 2006; 115(2):220-8. DOI: 10.1016/j.ijcard.2006.03.028. View

Abbott J, Huang Y, Liu D, Hickey R, Krause D, Giordano F . Stromal cell-derived factor-1alpha plays a critical role in stem cell recruitment to the heart after myocardial infarction but is not sufficient to induce homing in the absence of injury. Circulation. 2004; 110(21):3300-5. DOI: 10.1161/01.CIR.0000147780.30124.CF. View

Bhakta S, Hong P, Koc O . The surface adhesion molecule CXCR4 stimulates mesenchymal stem cell migration to stromal cell-derived factor-1 in vitro but does not decrease apoptosis under serum deprivation. Cardiovasc Revasc Med. 2006; 7(1):19-24. DOI: 10.1016/j.carrev.2005.10.008. View

Kristocheck M, Dias L, Ghem C, Eibel B, Kalil R, Markoski M . The homing of bone marrow stem cells is differentially activated in ischemic and valvular heart diseases and influenced by beta-blockers. J Transl Med. 2018; 16(1):133. PMC: 5963100. DOI: 10.1186/s12967-018-1520-9. View

Mehmood A, Ali M, Khan S, Riazuddin S . Diazoxide preconditioning of endothelial progenitor cells improves their ability to repair the infarcted myocardium. Cell Biol Int. 2015; 39(11):1251-63. DOI: 10.1002/cbin.10498. View

Li Z, Zhang C, Weiner L, Zhang Y, Zhong J . Molecular characterization of heterogeneous mesenchymal stem cells with single-cell transcriptomes. Biotechnol Adv. 2012; 31(2):312-7. PMC: 3767306. DOI: 10.1016/j.biotechadv.2012.12.003. View

Naji A, Eitoku M, Favier B, Deschaseaux F, Rouas-Freiss N, Suganuma N . Biological functions of mesenchymal stem cells and clinical implications. Cell Mol Life Sci. 2019; 76(17):3323-3348. PMC: 11105258. DOI: 10.1007/s00018-019-03125-1. View

Ziegler M, Elvers M, Baumer Y, Leder C, Ochmann C, Schonberger T . The bispecific SDF1-GPVI fusion protein preserves myocardial function after transient ischemia in mice. Circulation. 2012; 125(5):685-96. DOI: 10.1161/CIRCULATIONAHA.111.070508. View

10.

Salazar-Noratto G, Luo G, Denoeud C, Padrona M, Moya A, Bensidhoum M . Understanding and leveraging cell metabolism to enhance mesenchymal stem cell transplantation survival in tissue engineering and regenerative medicine applications. Stem Cells. 2019; 38(1):22-33. DOI: 10.1002/stem.3079. View

11.

Zhang D, Huang W, Dai B, Zhao T, Ashraf A, Millard R . Genetically manipulated progenitor cell sheet with diprotin A improves myocardial function and repair of infarcted hearts. Am J Physiol Heart Circ Physiol. 2010; 299(5):H1339-47. PMC: 2993193. DOI: 10.1152/ajpheart.00592.2010. View

12.

Shan S, Liu Z, Guo T, Wang M, Tian S, Zhang Y . Growth arrest-specific gene 6 transfer promotes mesenchymal stem cell survival and cardiac repair under hypoxia and ischemia via enhanced autocrine signaling and paracrine action. Arch Biochem Biophys. 2018; 660:108-120. DOI: 10.1016/j.abb.2018.10.016. View

13.

Heng B, Hsu S, Cowan C, Liu A, Tai J, Chan Y . Transcatheter injection-induced changes in human bone marrow-derived mesenchymal stem cells. Cell Transplant. 2009; 18(10):1111-21. DOI: 10.3727/096368909X12483162197006. View

14.

Goldstone A, Burnett C, Cohen J, Paulsen M, Eskandari A, Edwards B . SDF 1-alpha Attenuates Myocardial Injury Without Altering the Direct Contribution of Circulating Cells. J Cardiovasc Transl Res. 2018; 11(4):274-284. PMC: 6103912. DOI: 10.1007/s12265-017-9772-y. View

15.

He H, Zhao Z, Han F, Liu X, Wang R, Zeng Y . Overexpression of protein kinase C ɛ improves retention and survival of transplanted mesenchymal stem cells in rat acute myocardial infarction. Cell Death Dis. 2016; 7:e2056. PMC: 4816190. DOI: 10.1038/cddis.2015.417. View

16.

Shahzad U, Li G, Zhang Y, Yau T . Transmyocardial revascularization induces mesenchymal stem cell engraftment in infarcted hearts. Ann Thorac Surg. 2012; 94(2):556-62. DOI: 10.1016/j.athoracsur.2012.03.048. View

17.

Jiang Q, Song P, Wang E, Li J, Hu S, Zhang H . Remote ischemic postconditioning enhances cell retention in the myocardium after intravenous administration of bone marrow mesenchymal stromal cells. J Mol Cell Cardiol. 2013; 56:1-7. DOI: 10.1016/j.yjmcc.2012.12.016. View

18.

Lovshin J, Rajasekeran H, Lytvyn Y, Lovblom L, Khan S, Alemu R . Dipeptidyl Peptidase 4 Inhibition Stimulates Distal Tubular Natriuresis and Increases in Circulating SDF-1α in Patients With Type 2 Diabetes. Diabetes Care. 2017; 40(8):1073-1081. DOI: 10.2337/dc17-0061. View

19.

Chacko S, Ahmed S, Selvendiran K, Kuppusamy M, Khan M, Kuppusamy P . Hypoxic preconditioning induces the expression of prosurvival and proangiogenic markers in mesenchymal stem cells. Am J Physiol Cell Physiol. 2010; 299(6):C1562-70. PMC: 3006322. DOI: 10.1152/ajpcell.00221.2010. View

20.

Facklam A, Volpatti L, Anderson D . Biomaterials for Personalized Cell Therapy. Adv Mater. 2019; 32(13):e1902005. DOI: 10.1002/adma.201902005. View